Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas

The Journal of Clinical Endocrinology and Metabolism
D FeroneG Lombardi

Abstract

The efficacy of dopaminergic agents in the medical treatment of pituitary adenomas is well known. Quinagolide is a nonergot derivative dopamine agonist, which binds dopamine D2 receptors with high affinity. The treatment with this drug is reported to suppress hormone levels and to cause tumor shrinkage in prolactinomas and in a few GH-secreting pituitary adenomas. In clinically nonfunctioning pituitary adenomas (NFPA), the efficacy of quinagolide treatment is controversial. The scintigraphy of the pituitary region using 123I-methoxybenzamide (123I-IBZM) allows us to visualize in vivo the expression of dopamine D2 receptors on pituitary tumors. In this study, the pituitary scintigraphy with 123I-IBZM was performed in 14 patients with macroadenoma before starting a long-term treatment with quinagolide: 6 NFPA with high circulating alpha-subunit levels, 4 PRL-secreting, and 4 GH-secreting adenomas. A 3-point score was used to grade the ligand accumulation within the pituitary adenomas: 0 = negative, 1 = moderate uptake (equal to that recorded in the cerebral cortex), and 2 = intense uptake (equal to that recorded in the basal nuclei). The treatment with quinagolide was carried out at the dose of 0.3-0.6 mg/day for 6-12 months. Cli...Continue Reading

Citations

May 31, 2002·Expert Opinion on Investigational Drugs·Annamaria ColaoGaetano Lombardi
Nov 14, 1998·Annals of Medicine·A ColaoG Lombardi
Apr 7, 2007·European Journal of Endocrinology·Annamaria ColaoGaetano Lombardi
Sep 16, 2008·Reviews in Endocrine & Metabolic Disorders·Annamaria ColaoGaetano Lombardi
Mar 16, 2001·Expert Opinion on Pharmacotherapy·A ColaoL Annunziato
Sep 10, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ambika BabuLeon Fogelfeld
Apr 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Rosario PivonelloGaetano Lombardi
Dec 14, 1999·Journal of Endocrinological Investigation·A ColaoG Lombardi
Sep 7, 2018·Frontiers in Endocrinology·Odelia Cooper, Yona Greenman
Sep 15, 2019·European Journal of Internal Medicine·Pedro IglesiasJuan José Díez

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