Correlation of Serum Biomarkers and Magnetic Resonance Spectroscopy in Monitoring Disease Progression in Patients With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Due to mtDNA A3243G Mutation

Frontiers in Neurology
Ha Neul LeeYoung-Mock Lee

Abstract

Background: Analysis of serum biomarkers and magnetic resonance spectroscopy (MRS) are useful for monitoring disease progression in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). We evaluated the correlation of serum biomarkers and MRS parameters during changes associated with stroke-like episodes. Methods: In 13 symptomatic MELAS patients carrying the A3243G mutation, we retrospectively obtained 207 voxels from 41 MRS studies, which were divided into three groups according to the temporal association with stroke-like episodes. The MRS NAA/Cr, Cho/Cr, NAA/Cho ratios, the presence of a lactate peak, serum biomarkers, serum lactate level and the pyruvate (Lac/Pyr) ratio were determined. Results: In regions with acute infarcts, the severity of serum Lac/Pyr and that of the MRS lactate peak (P = 0.0007) correlated; serum lactate (P = 0.02), severity of elevated serum lactate (P = 0.04), and serum Lac/Pyr (P = 0.02) correlated weakly. In previously infarcted regions, the severity of the MRS lactate peak and serum Lac/Pyr (P = 0.03), as well as the severity of serum Lac/Pyr (P = 0.02) were weakly correlated. In structurally normal regions, we found a weak to moderate negative correla...Continue Reading

References

Mar 12, 2005·Journal of the Neurological Sciences·Harald E MöllerBarbara Fiedler
Jul 21, 2006·Molecular Genetics and Metabolism·Brian H Robinson
Feb 22, 2008·Brain & Development·Hiromichi ItoShoji Kagami
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Mar 30, 2011·Biochimica Et Biophysica Acta·Shuichi YatsugaUNKNOWN Taro Matsuoka for MELAS Study Group in Japan
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Oct 21, 2015·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Marjan TaherMichèl A Willemsen

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Citations

Aug 23, 2020·International Journal of Molecular Sciences·Maryam GulAmmar Chaudhry
Aug 23, 2019·Annual Review of Nutrition·Xuan YangZhenglong Gu

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Methods Mentioned

BETA
biopsy
sedation

Software Mentioned

Functool
PRESS
SPSS

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