Correlation of Serum Creatine Kinase Level With Pulmonary Function in Duchenne Muscular Dystrophy

Annals of Rehabilitation Medicine
Eun Young KimHyeonjun Oh

Abstract

To investigate the relationship between serum creatine kinase (CK) level and pulmonary function in Duchenne muscular dystrophy (DMD). A total of 202 patients with DMD admitted to the Department of Rehabilitation Medicine, Gangnam Severance Hospital were enrolled from January 1, 1999 to March 31, 2015. Seventeen patients were excluded. Data collected from the 185 patients included age, height, weight, body mass index, pulmonary function tests including forced vital capacity (FVC), peak cough flow, maximal expiratory pressure (MEP), and maximal inspiratory pressure (MIP), and laboratory measurements (serum level of CK, CK-MB, troponin-T, and B-type natriuretic peptide). FVC, MEP, and MIP were expressed as percentages of predicted normal values. Serum CK activities were elevated above normal levels, even in the oldest DMD group. Serum CK level was strongly correlated with pulmonary functions of sitting FVC (p<0.001), supine FVC (p<0.001), MIP (p=0.004), and MEP (p<0.001). Serum CK level is a reliable screening test even in patients with advanced DMD, and is a strong predictor of pulmonary functions.

References

Jan 1, 1972·Chest·E J HapkeJ Jacobs
Mar 1, 1981·Muscle & Nerve·Y RideauJ Grellet
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·M F PhillipsP M Calverley
Dec 13, 2006·Pediatric Neurology·Nicolas Deconinck, Bernard Dan
Jun 7, 2012·European Journal of Human Genetics : EJHG·Apollonia T J M Helderman-van den EndenHendrika B Ginjaar
Jul 22, 2014·Muscle & Nerve·Katharine BushbyUNKNOWN PTC124-GD-007-DMD STUDY GROUP

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Citations

Jan 18, 2018·Expert Review of Proteomics·Sandra MurphyKay Ohlendieck
Sep 9, 2018·Nature Communications·Jennifer E MorganMaximilien Bencze
Dec 18, 2020·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Iván Rodríguez-NúñezDaniel Zenteno
Oct 28, 2020·International Journal of Molecular Sciences·Heta LadPenney M Gilbert

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