Correlation of Serum Vitamin D Level with Mortality in Patients with Sepsis

Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine
Prakash VipulPrakash Ved

Abstract

Sepsis is the leading cause of mortality in the critically ill. Recently, it has been found in many studies that many trace elements and nutrients do have an effect on human body and if supplemented can improve the prognosis in patients with sepsis. Primary objective: Whether low Vitamin D is associated with mortality. Secondary objective: To find out association of low Vitamin D levels and morbidity in terms of length of hospital and Intensive Care Unit (ICU) stay. Following ethical approval, consent will be sought from either the patient or assent from a near relative. Successive patients admitted to the medical emergency and ICU at tertiary care health center who fulfill the following criteria for sepsis, within a 24 h time window, were included in the study. Among 88 patients evaluated in our study 15 patients (18.2%) were found to have adequate Vitamin D levels and seven patients (8%) were found insufficient and rest 52 patients (73.9%) were found deficient in Vitamin D. Age of the patients ranged between 18 and 82 years with mean (±standard deviation) 45.02 ± 17.69 years. Mean Vitamin D level was found significantly higher among patients with positive outcome than those with unfavorable outcome (expiry) (t = 2.075, P = 0....Continue Reading

References

Mar 11, 2008·Annals of Epidemiology·Michael F Holick
Oct 16, 2008·The Journal of Clinical Endocrinology and Metabolism·Daniel Bikle
Aug 17, 2011·Reviews in Endocrine & Metabolic Disorders·John H White
Dec 14, 2011·Critical Care : the Official Journal of the Critical Care Forum·Sindhaghatta VenkatramGilda Diaz-Fuentes

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Citations

Mar 29, 2018·PloS One·Jared A JaffeyAmy E DeClue
Sep 15, 2017·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Suresh Kumar Angurana, Vishal Guglani
Jul 19, 2020·Nutrients·Nipith Charoenngam, Michael F Holick
Mar 22, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Nipith CharoenngamMichael F Holick

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