PMID: 22355997Feb 24, 2012Paper

Correlation of splenectomy with portal vein thrombosis in beta-thalassemia major

JPMA. the Journal of the Pakistan Medical Association
Mahmoodi Nesheli HassanMahmoodi Nesheli Mohsen

Abstract

To evaluate the correlation of portal vein thrombosis and splenectomy in beta-thalassemia major patients visiting Babol Medical University, Iran. This cohort study was done from 1997 to 2008. In our study, major beta-thalassemic patients visiting for transfusion at least once a month at Amirkola Children's Hospital were selected. Portal vein thrombosis was diagnosed through Doppler ultrasound in symptomatic patients. Cases were 160 beta-thalassemia major patients who underwent splenectomy and 160 remaining thalassemic patients without splenectomy were controls. Statistical comparison with Fisher exact test was performed. Five cases had suffered from portal vein thrombosis (P = 0.03). Majority patients with portal vein thrombosis had their symptoms after first month of the operation. Correlation of splenectomy with portal vein thrombosis is statistically significant among beta-thalassemic children from Iran.

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