Correlation of Synaptic Inputs in the Visual Cortex of Awake, Behaving Mice

Neuron
Sergio ArroyoShaul Hestrin

Abstract

The subthreshold mechanisms that underlie neuronal correlations in awake animals are poorly understood. Here, we perform dual whole-cell recordings in the visual cortex (V1) of awake mice to investigate membrane potential (Vm) correlations between upper-layer sensory neurons. We find that the membrane potentials of neighboring neurons display large, correlated fluctuations during quiet wakefulness, including pairs of cells with disparate tuning properties. These fluctuations are driven by correlated barrages of excitation followed closely by inhibition (∼5-ms lag). During visual stimulation, low-frequency activity is diminished, and coherent high-frequency oscillations appear, even for non-preferred stimuli. These oscillations are generated by alternating excitatory and inhibitory inputs at a similar lag. The temporal sequence of depolarization for pairs of neurons is conserved during both spontaneous- and visually-evoked activity, suggesting a stereotyped flow of activation that may function to produce temporally precise "windows of opportunity" for additional synaptic inputs.

Citations

Apr 7, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tang-Yu Liu, Brendon O Watson
Jul 31, 2020·Journal of Neurophysiology·Jean-Philippe Thivierge
Jan 24, 2019·Frontiers in Systems Neuroscience·James F A Poulet, Sylvain Crochet
Jun 4, 2019·Frontiers in Synaptic Neuroscience·Jean-Sébastien Jouhanneau, James F A Poulet
Nov 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·Pei-Ann LinJeffry S Isaacson
Aug 28, 2021·Trends in Neurosciences·Anderson Speed, Bilal Haider
Dec 29, 2021·PLoS Computational Biology·Daniel Müller-KomorowskaIlan Lampl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.