Correlation of T-channel coding gene expression, IT, and the low threshold Ca2+ spike in the thalamus of a rat model of absence epilepsy

Molecular and Cellular Neurosciences
Tilman BroicherThomas Budde

Abstract

T-type Ca(2+) current-dependent burst firing of thalamic neurons is thought to be involved in the hyper-synchronous activity observed during absence seizures. Here we investigate the correlation between the expression of T-channel coding genes (alpha1G, -H, -I), T-type Ca(2+) current, and the T-current-dependent low threshold Ca(2+) spike in three functionally distinct thalamic nuclei (lateral geniculate nucleus; centrolateral nucleus; reticular nucleus) in a rat model of absence epilepsy, the WAG/Rij rats, and a non-epileptic control strain, the ACI rats. The lateral geniculate nucleus and centrolateral nucleus were found to primarily express alpha1G and alpha1I, while the reticular thalamic nucleus expressed alpha1H and alpha1I. Expression was higher in WAG/Rij when compared to ACI. The T-type Ca(2+) current properties matched the predictions derived from the expression pattern analysis. Current density was larger in all nuclei of WAG/Rij rats when compared to ACI and correlated with LTS size and the minimum LTS generating slope, while T-type Ca(2+) current voltage dependency correlated with the LTS onset potential.

References

Mar 13, 1989·Neuroscience Letters·D A CoulterD A Prince
Sep 30, 1998·The European Journal of Neuroscience·T SeidenbecherH C Pape
Jan 29, 2000·Brain Research. Molecular Brain Research·E M TalleyD A Bayliss
Jul 7, 2001·Epilepsia·M AvoliG Avanzini
Aug 11, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·M L Hines, N T Carnevale
May 4, 2002·Nature Reviews. Neuroscience·Vincenzo Crunelli, Nathalie Leresche
Sep 12, 2002·Network : Computation in Neural Systems·Arjen van OoyenJaap van Pelt
Dec 31, 2002·Physiological Reviews·Edward Perez-Reyes
Mar 1, 1953·Brain : a Journal of Neurology·D WILLIAMS
Jun 4, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yi ZhangJeffrey L Noebels
Jan 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Matthew P AndersonSusumu Tonegawa
Oct 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas BuddeHans-Christian Pape
Mar 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kate L BlethynVincenzo Crunelli
Jun 9, 2006·Cell Calcium·E Perez-Reyes
Jun 17, 2006·Cell Calcium·Vincenzo CrunelliStuart W Hughes
Jan 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeanne Tamar PazStéphane Charpier
Apr 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carolyn J LaceyPeter J Magill
Apr 28, 2007·The Journal of Physiology·Sang-Hun LeeCharles L Cox
Jan 1, 2005·Thalamus & Related Systems·Didier Pinault, Terence J O'Brien

❮ Previous
Next ❯

Citations

Jan 22, 2010·Pflügers Archiv : European journal of physiology·Gerald W ZamponiEdward Perez-Reyes
Mar 26, 2011·Pflügers Archiv : European journal of physiology·Tatyana KanyshkovaThomas Budde
Sep 14, 2011·Pflügers Archiv : European journal of physiology·Philippe CoulonHans-Christian Pape
Dec 5, 2012·Pflügers Archiv : European journal of physiology·Petra EhlingThomas Budde
Jul 8, 2009·Cell Biochemistry and Biophysics·Victor N UebeleJohn J Renger
Apr 26, 2012·Journal of Molecular Neuroscience : MN·Petra EhlingThomas Budde
Aug 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Simone AstoriAnita Lüthi
Feb 13, 2014·Pflügers Archiv : European journal of physiology·Eunji Cheong, Hee-Sup Shin
Nov 28, 2013·The Journal of Physiology·Veit-Simon EckleEdward Perez-Reyes
Dec 23, 2009·Brain Research Reviews·Marco WeiergräberRüdiger Köhling
Jul 28, 2009·Neurobiology of Disease·N SuntsovaD McGinty
Jun 24, 2011·BioFactors·Stuart M Cain, Terrance P Snutch
Jul 10, 2013·British Journal of Clinical Pharmacology·Kim L PowellTerence J O'Brien
Aug 10, 2015·Molecular and Cellular Neurosciences·Johanna G PasekRoger J Colbran
Aug 14, 2012·Biochimica Et Biophysica Acta·Stuart M Cain, Terrance P Snutch
Apr 5, 2011·Neurobiology of Disease·Ali GorjiHans-Christian Pape
Nov 30, 2010·Molecular and Cellular Neurosciences·Johannes Brockhaus, Hans-Christian Pape
Jun 24, 2014·Pflügers Archiv : European journal of physiology·Stuart M CainTerrance P Snutch
Dec 9, 2010·Channels·Stuart M Cain, Terrance P Snutch
Oct 28, 2014·Pflügers Archiv : European journal of physiology·Pawan BistaThomas Budde
Feb 19, 2013·Biochimica Et Biophysica Acta·Eunji Cheong, Hee-Sup Shin
Jun 12, 2016·Journal of Theoretical Biology·Petra EhlingSven G Meuth
Oct 30, 2016·Neuroscience and Biobehavioral Reviews·Emilio RussoGiovambattista De Sarro
Aug 1, 2013·Physiological Reviews·Eunji Cheong, Hee-Sup Shin
Dec 5, 2019·Brain : a Journal of Neurology·Qing-Long MiaoJeffrey L Noebels
Oct 2, 2020·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yasushi Yabuki
Oct 28, 2019·Molecular Brain·Ivana A SouzaGerald W Zamponi
Jul 9, 2020·Pflügers Archiv : European journal of physiology·Philippe LoryArnaud Monteil
Mar 12, 2021·Brain : a Journal of Neurology·Yousra El GhalebBernhard E Flucher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.