PMID: 9272528Aug 1, 1997Paper

Correlation of the heart rate-minute ventilation relationship with clinical data: relevance to rate-adaptive pacing

Pacing and Clinical Electrophysiology : PACE
L P SoucieA S Tang

Abstract

The heart rate (HR)-minute ventilation (VE) relationship has been shown to be nonlinear and can be expressed as two distinct straight lines. This study is to assess the correlation of the initial HR-VE slope to clinical parameters. Maximum treadmill exercise tests were performed in 100 healthy volunteers (age 19-77 years) using a ramp protocol in which work-rate increases linearly with exercise. Breath-by-breath VO2, VCO2, and VE were measured, and HR and BP were monitored throughout the exercise. The HR-VE curve demonstrated nonlinearity with a breakpoint determined by a change point analysis. This breakpoint was significantly higher than that of the anaerobic threshold. The VE at the HR-VE breakpoint was 56.4 +/- 19.4 and VE at the VE-VO2-VO2 breakpoints were 48.0 +/- 18.3 (P < 0.0001) and 40.1 +/- 16.5 (P < 0.0001), respectively. The HR at this HR-Ve breakpoint was 77.7 +/- 12.9% of the HR range. The first slope, S1 (1.76 +/- 0.64) was steeper than the second slope, S2 (0.66 +/- 0.39). Although there was a gender difference for S1, the best clinical predictor on a stepwise multiple regression analysis was body surface area (BSA) which explained 47% of the variance. It was concluded that nonlinearity of the HR-VE curve can be...Continue Reading

References

May 1, 1991·Pacing and Clinical Electrophysiology : PACE·M A OtoS Ugurlu
Mar 1, 1991·Journal of the American College of Cardiology·N SulkeE Sowton
Jan 1, 1985·Pacing and Clinical Electrophysiology : PACE·D P HumenG J Klein
Jan 1, 1985·Pacing and Clinical Electrophysiology : PACE·B E KristenssonL Rydén
Jun 1, 1986·Journal of Applied Physiology·W L BeaverB J Whipp
Jan 1, 1988·Journal of the American College of Cardiology·P A McElroyK T Weber
Mar 1, 1983·Pacing and Clinical Electrophysiology : PACE·P RossiF Aina
May 1, 1983·Pacing and Clinical Electrophysiology : PACE·L FananapazirP Monks
Aug 1, 1993·Pacing and Clinical Electrophysiology : PACE·N TreeseJ Meyer

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Citations

Mar 31, 2006·Archives of Physical Medicine and Rehabilitation·Delphine DavidFrédéric Lofaso
Apr 5, 2019·Journal of Occupational and Environmental Medicine·Cara M SmithAimee M Layton
Sep 7, 2018·Journal of Exposure Science & Environmental Epidemiology·N GoodJ Volckens

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