Correlation of the lung microbiota with metabolic profiles in bronchoalveolar lavage fluid in HIV infection

Microbiome
Sushma K CribbsAlison Morris

Abstract

While 16S ribosomal RNA (rRNA) sequencing has been used to characterize the lung's bacterial microbiota in human immunodeficiency virus (HIV)-infected individuals, taxonomic studies provide limited information on bacterial function and impact on the host. Metabolic profiles can provide functional information on host-microbe interactions in the lungs. We investigated the relationship between the respiratory microbiota and metabolic profiles in the bronchoalveolar lavage fluid of HIV-infected and HIV-uninfected outpatients. Targeted sequencing of the 16S rRNA gene was used to analyze the bacterial community structure and liquid chromatography-high-resolution mass spectrometry was used to detect features in bronchoalveolar lavage fluid. Global integration of all metabolic features with microbial species was done using sparse partial least squares regression. Thirty-nine HIV-infected subjects and 20 HIV-uninfected controls without acute respiratory symptoms were enrolled. Twelve mass-to-charge ratio (m/z) features from C18 analysis were significantly different between HIV-infected individuals and controls (false discovery rate (FDR) = 0.2); another 79 features were identified by network analysis. Further metabolite analysis demonst...Continue Reading

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Datasets Mentioned

BETA
SRP065274

Methods Mentioned

BETA
bronchoalveolar
lavage

Clinical Trials Mentioned

NCT00870857

Software Mentioned

Bioconductor
apLCMS
NCSS
R package mixOmics
xMSanalyzer
Mummichog
InfoMetrix
Pirouette
Metabolome
R

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