Correlation of thrombus formation on 7 T MRI with histology in a rat carotid artery side wall aneurysm model

Journal of Neurointerventional Surgery
Chao ZhangAditya S Pandey

Abstract

Various aneurysm animal models have been utilized to study the histological reaction post coil embolization. Our aim was to evaluate the imaging findings at day 14 of a rat external carotid artery side wall aneurysm treated with coil embolization using a gradient echo sequence on 7 T MRI and to correlate this with the histological findings. Male Sprague Drawley rats were utilized to create a sidewall external carotid artery blind pouch aneurysm. A 5 mm segment of hydrocoil or bare platinum coil was inserted into the created aneurysm. Five sham operated rats were used as controls. The arterial construct was harvested on day 14. The block of tissue was evaluated with histopathology and immunohistochemistry. Prior to sacrifice, the animal underwent 7 T MRI. Statistical analysis was then performed to assess the correlation of signal abnormality with intra-aneurysmal thrombus formation on histology. 10 rats were used for the experiment. Five rats had implantation of hydrocoils and five of bare platinum coils. There was a statistically significant linear correlation between the intra-aneurysmal thrombus on histology and gradient echo 7 T MRI sequences. There was no correlation demonstrated in the hydrocoil implanted group. No thrombu...Continue Reading

References

Jul 4, 2006·Current Problems in Diagnostic Radiology·Yoshito Tsushima, Keigo Endo
Sep 27, 2007·Journal of Magnetic Resonance Imaging : JMRI·Cornelius von MorzeDaniel B Vigneron
Dec 31, 2008·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·C MönninghoffI Wanke
Sep 17, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Govind B ChavhanE Mark Haacke
Sep 23, 2011·European Journal of Radiology·Anja G van der KolkPeter R Luijten
Jan 30, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Tomonobu Kodama, Hiroo Iwata
Apr 30, 2013·Journal of Neurosurgery·Andrew MolyneuxJacqueline Birks
Apr 30, 2013·Journal of Neurosurgery·Robert F SpetzlerRobert C Wallace

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Citations

Dec 25, 2019·Journal of Neurointerventional Surgery·Edin NevzatiSerge Marbacher
May 19, 2020·Current Pharmaceutical Design·Paraskevi PapanikolaouDimitris Tousoulis

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