Correlation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma.

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Ilwoo ParkSarah J Nelson

Abstract

The purpose of this study was to compare C-13 imaging parameters with hyperpolarized [1-13C]pyruvate with conventional gadolinium (Gd)-based perfusion weighted imaging using an orthotopic xenograft model of human glioblastoma multiforme (GBM). C-13 3D magnetic resonance spectroscopic imaging (MRSI) data were obtained from 14 tumor-bearing rats after the injection of hyperpolarized [1-13C]pyruvate at a 3T scanner. Dynamic susceptibility contrast (DSC) perfusion-weighted MR images were obtained following intravenous administration of Gd-DTPA. Normalized lactate, pyruvate, total carbon, and lactate to pyruvate ratio from C-13 MRSI data were compared with normalized peak height and percent recovery of ΔR2* curve from the DSC images in the voxels containing tumor using a Pearson's linear correlation. Normalized peak height from DSC imaging showed substantial correlations with normalized lactate (r = 0.6, p = 0.02) and total carbon (r = 0.6, p = 0.02) from hyperpolarized C-13 MRSI data. Since the peak height in the ΔR2* curve from DSC data is related to the extent of blood volume, these hyperpolarized C-13 imaging parameters may be used to assess blood volume in rodent intracranial xenograft models of GBM.

References

Aug 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jan H Ardenkjaer-LarsenKlaes Golman
Sep 28, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Charles H CunninghamJohn M Pauly
Aug 4, 2006·Journal of the American Society of Nephrology : JASN·Peter MarckmannHenrik S Thomsen
Jun 15, 2007·Journal of Magnetic Resonance·Charles H CunninghamDaniel B Vigneron
Jul 12, 2007·Journal of Magnetic Resonance Imaging : JMRI·Tristan BarrettPeter L Choyke
Feb 27, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peder E Z LarsonDaniel B Vigneron
Jan 26, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sam E DayKevin M Brindle
May 13, 2011·Journal of Magnetic Resonance Imaging : JMRI·Cornelius von MorzeDaniel B Vigneron
Aug 2, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ilwoo ParkSarah J Nelson
Aug 14, 2015·Brain Pathology·Cara J ValvonaGeoffrey J Pilkington
Sep 26, 2015·Physical Chemistry Chemical Physics : PCCP·Enrico RaveraGiacomo Parigi
Jan 9, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Angus Z LauDamian J Tyler
Feb 20, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ilwoo ParkSarah J Nelson
Feb 24, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jeremy W GordonPeder E Z Larson
Sep 17, 2016·Circulation Research·Charles H CunninghamKim A Connelly
Jan 13, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ilwoo ParkSarah J Nelson
Mar 31, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bradley T ScrogginsDeborah E Citrin

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Citations

Aug 23, 2019·NMR in Biomedicine·Lydia M Le PageMyriam M Chaumeil
Jan 15, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Ilwoo ParkJean L Nakamura

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