Correlation of ultrasonic and endocrinologic measurements in human menopausal gonadotropin therapy

American Journal of Obstetrics and Gynecology
R P MarrsC M March

Abstract

Ultrasonographic measurement of follicle growth and estradiol concentrations have been shown to correlate well in spontaneous and Clomid-induced ovulatory cycles. However, little is known about these changes during human menopausal gonadotropin (hMG) therapy. Twenty-five women who did not ovulate when treated with clomiphene were treated with hMG during 70 treatment cycles. Eleven patients had withdrawal bleeding after progesterone administration (group 1) and 14 did not bleed (group 2). Follicle growth was monitored with intermittent serum estrogen determinations and daily ovarian ultrasound with an ADR Model 2140 real-time sector scanner. The mean dominant follicle size at the time of human chorionic gonadotropin (hCG) injection was 21.2 mm +/- 0.6 (SEM) and was not different between the two groups. Mean serum estrogen level at the time of hCG injection was 1,121 pg/ml and correlated with follicle volume. At the time of hCG injection in group 2, one dominant follicle was present in 65% and two were present in 35% of the patients. Among those in group 1, two or more dominant follicles were present during all cycles. Mean serum estrogen levels were significantly higher in group 1 patients than those in group 2. This "chemical h...Continue Reading

Citations

Mar 1, 1996·Clinical Obstetrics and Gynecology·M J Nachtigall, L B Schwartz
Dec 1, 1984·Journal of in Vitro Fertilization and Embryo Transfer : IVF·B C TarlatzisA H Decherney
Jun 1, 1993·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J G FrancoJ B Oliveira
Dec 1, 1984·Journal of in Vitro Fertilization and Embryo Transfer : IVF·G S Prins, R L Vogelzang
Dec 1, 1986·Journal of in Vitro Fertilization and Embryo Transfer : IVF·F Sato, R P Marrs
Mar 1, 1984·Journal of in Vitro Fertilization and Embryo Transfer : IVF·R J YoungY M Javid
Jun 1, 1993·Asia-Oceania Journal of Obstetrics and Gynaecology·Y F ChanG W Tang
Feb 1, 1997·Endocrine Reviews·B C Fauser, A M Van Heusden

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