Correlation of vascular endothelial growth factor-C expression with tumor-infiltrating dendritic cells in gastric cancer

Oncology
Akihiro TakahashiYoshiro Matsumoto

Abstract

It has been reported that dendritic cells (DCs) play a crucial role in the host's immune defense against tumors, and there is an inverse correlation between the density of DCs and the expression of vascular endothelial growth factor (VEGF). However, the relationship between the expression of VEGF-C and DC infiltration remained unclear. In the present study, we investigated whether the expression of VEGF-C correlated with the number of DCs in vivo. We immunohistochemically analyzed gastric carcinoma tissue in this study. The survival curves show that the prognosis for patients with a low density of DCs was significantly poorer than that for patients with high DC density (p < 0.01). Further, the survival curves according to the VEGF-C status showed that the survival rate in patients with low VEGF-C expression was higher than that in patients with higher expression (p < 0.01). There was a significant negative correlation between the density of DCs and the expression of VEGF-C (r = -0.26, p < 0.05). We suggest that VEGF-C produced by cancer causes DCs to become dysfunctional. This may be one of the ways that cancers evade immunosurveillance.

Citations

Aug 7, 2012·Genes & Cancer·Ailsa Christiansen, Michael Detmar
Apr 6, 2007·Biological & Pharmaceutical Bulletin·Kenji KondoHiroyuki Konno
Jan 9, 2010·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Soo Jung LeeWansik Yu
Dec 7, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weiguo CaoYunlin Wu
Mar 22, 2007·Expert Opinion on Biological Therapy·Benjamin F JohnsonMichael A Morse
May 16, 2008·Journal of Cellular Physiology·Matthias Rinderknecht, Michael Detmar
Feb 25, 2006·Journal of Biotechnology·Wilko Thiele, Jonathan P Sleeman
Sep 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Lei LiuYu-Quan Wei
Jul 17, 2012·The American Journal of Pathology·Nina KarthausJurjen Tel
Mar 1, 2006·International Journal of Oral and Maxillofacial Surgery·Z WangS Li
Dec 14, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefan JüttnerMichael Höcker
Jul 7, 2011·Journal of Immunoassay & Immunochemistry·Chen ChengJian-An Huang
Dec 24, 2008·Virchows Archiv : an International Journal of Pathology·Hiroshi MoritaToshiharu Ishii
Feb 19, 2019·Médecine sciences : M/S·Papa Diogop Ndiaye, Gilles Pagès
Dec 17, 2004·Pharmacological Reviews·Ann HoebenErnst A De Bruijn
Dec 21, 2002·Immunological Reviews·Naoyuki TsuchiyaKatsushi Tokunaga
Apr 19, 2015·Experimental Biology and Medicine·Chu-An Wang, Shaw-Jenq Tsai
Feb 6, 2013·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Déborah RossoLaércio G Lourenço

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.