Correlation of viral load with bone marrow and hematological changes in pale patients with chronic hepatitis C virus

Archives of Virology
Abdel Raouf Abou El AzmMohamed Labib Salem

Abstract

Liver is considered the target of hepatitis C virus (HCV), which has marked tropism for hepatocytes. In this study, we investigated changes in bone marrow (BM) and blood and their correlation with viremia level in 30 pale patients with chronic HCV who were selected before antiviral therapy. Patients with BM positive for HCV RNA (53.33 %) showed moderate to high viremia, while patients with BM negative for RNA (46.67 %) had low viremia. There was no significant difference in the liver histopathology between patients with HCV-RNA-negative and positive BM. Patients with BM positive for HCV RNA showed significant changes in BM cells, including the degree of immune complex deposition and alterations in peripheral blood counts compared to patients with BM negative for RNA and healthy controls, suggesting that BM changes could be a sequel or a reservoir for HCV viremia.

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Citations

Aug 31, 2016·International Journal of Laboratory Hematology·J M Boone, W Cui
Sep 10, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yoji IshizuMitsuhiro Fujishiro
Nov 22, 2013·Current Opinion in Hematology·Vivien A SheehanBradford Waters
Jan 26, 2021·Frontline Gastroenterology·Annapoorani VaradarajanChhagan Bihari

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