Correlation of volume transfer coefficient Ktrans with histopathologic grades of gliomas.

Journal of Magnetic Resonance Imaging : JMRI
Na ZhangBob L Hou

Abstract

To evaluate the roles of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and optimum tracer kinetic parameters in the noninvasive grading of the glial brain tumors with histopathological grades (I-IV). Twenty-eight patients with histopathologically graded gliomas were imaged. Images with five flip angles were acquired before injection of gadolinium-DTPA and were processed to calculate the T(1) value of each region of interest (ROI). All the DCE-MRI data acquired during the injection were processed based on the MRI signal and pharmacokinetic models to establish concentration-time curves in the ROIs drawn within the tumors, contralateral normal areas, and area of the individual artery input functions (iAIF) of each patient. A nonlinear least-square-fitting method was used to obtain tracer kinetic parameters. Kruskal-Wallis H-test and Mann-Whitney U-test were applied to these parameters in different histopathological grade groups for statistical differences (P < 0.05). Volume transfer coefficient (K(trans) ) and extravascular extracellular space volume fraction (V(e) ) calculated using iAIFs can be used not only to distinguish the low (ie, I and II) from the high (ie, III and IV) grade gliomas (P( Ktrans) < 0.001 an...Continue Reading

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Dec 18, 2013·Neuroradiology·Christopher R DurstMax Wintermark
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