PMID: 15356377Sep 10, 2004Paper

Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit)

Journal of Atherosclerosis and Thrombosis
Masashi ShiomiJianglin Fan

Abstract

It is generally considered that coronary rupture-prone plaques play an important role in the onset of sudden cardiac events (acute coronary syndromes/sudden cardiac death). However, it is not clear which factors or stimuli are required to trigger plaque rupture and whether coronary plaques without occlusive thrombi can cause sudden cardiac events. To address these issues, recently, we developed a rabbit model of spontaneous myocardial infarction [the Watanabe heritable hyperlipidemic (WHHL) MI rabbit] and found that this model possessed several types of coronary plaques that are possibly correlated to sudden cardiac events. Although many of the coronary plaques of the WHHLMI rabbits appeared histologically to be rupture-prone in nature, true rupture was detected only in the few animals that died of MI. In addition, no occlusive thrombus was detected in any WHHLMI rabbit. These findings suggest that some additional stimuli play a definitive role in causing disruption of rupture-prone plaques and thrombosis. Nearly-occluded plaques caused by a luminal macrophage accumulation are the most common feature of WHHLMI rabbits, suggesting that they are responsible for sudden cardiac events. The WHHLMI rabbit could be a useful model for ...Continue Reading

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Citations

May 26, 2009·JACC. Cardiovascular Interventions·Yoriyasu SuzukiFumiaki Ikeno
Oct 7, 2008·Antioxidants & Redox Signaling·Anne C BrissetBrenda R Kwak
Jan 29, 2011·Journal of Biomedicine & Biotechnology·Gemma VilahurLina Badimon
Dec 25, 2009·Journal of Atherosclerosis and Thrombosis·Hiroshi OhkawaraYasuchika Takeishi
Mar 15, 2014·Nature Protocols·Zoltán IvicsZsuzsanna Izsvák
Mar 27, 2012·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Mowei SongYe Tian
Nov 6, 2008·Reproductive Biomedicine Online·Arata HondaAtsuo Ogura
Jan 22, 2011·Journal of Biomedicine & Biotechnology·Yoriyasu SuzukiFumiaki Ikeno
Jan 15, 2013·Vaccine·Jorge Alberto Salazar-González, Sergio Rosales-Mendoza
Jul 13, 2013·Scientific Reports·Leila B Mostaço-GuidolinMichael G Sowa
Jun 23, 2015·Fundamental & Clinical Pharmacology·Raman P Priyadharsini
Jul 25, 2013·The Journal of Biological Chemistry·Arata HondaAtsuo Ogura
Apr 29, 2011·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Olga LazouraNagy Habib
Jun 4, 2014·Analytical Chemistry·Leila B Mostaço-GuidolinAlex C-T Ko

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