Correlation with behavioral activity and rest implies circadian regulation by SCN neuronal activity levels

Journal of Biological Rhythms
Thijs HoubenJohanna H Meijer

Abstract

The SCN of the hypothalamus contains a major pacemaker, which exhibits 24-h rhythms in electrical impulse frequency. Although it is known that SCN electrical activity is high during the day and low during the night, the precise relationship between electrical activity and behavioral rhythms is almost entirely unknown. The authors performed long-term recordings of SCN multiple unit activity with the aid of implanted microelectrodes in parallel with the drinking activity in freely moving mice. The animals were kept in a 12h:12h light-dark cycle (LD 12:12) and in short-day (LD 8:16) and long-day photoperiods (LD 16:8). Onsets and offsets of behavioral activity occurred when SCN discharge was around half-maximum value. Of the onsets 80%, and of the offsets 62%, occurred when SCN electrical activity differed less than 15% from the half-maximum electrical activity levels. Transitions between rest and activity could be described by a sigmoid shaped probability curve with Hill coefficients of 7.0 for onsets and 5.7 for offsets. The similarity in the onset and offset levels shows an absence of hysteresis in the control of behavioral activity by the SCN. Exposure to short- or long-day photoperiods induced significant alterations in the w...Continue Reading

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Citations

Oct 15, 2013·Trends in Pharmacological Sciences·Analyne M Schroeder, Christopher S Colwell
Jul 6, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael C AntleJohanna H Meijer
Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Guadalupe Acosta-GalvanRuud M Buijs
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Feb 18, 2014·Mathematical Biosciences·Victoria Booth, Cecilia G Diniz Behn
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Apr 20, 2012·The European Journal of Neuroscience·Eliane A LucassenJohanna H Meijer
Dec 15, 2010·The European Journal of Neuroscience·Johanna H MeijerJos H T Rohling
Dec 3, 2014·Frontiers in Neuroendocrinology·Claudia P CoomansJohanna H Meijer
Feb 23, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jared W YoungDavide Dulcis
Feb 23, 2019·The European Journal of Neuroscience·Stephan Michel, Johanna H Meijer
Jun 13, 2020·Journal of Biological Rhythms·Michael C TackenbergDouglas G McMahon
Apr 17, 2020·Frontiers in Physiology·Bharath Ananthasubramaniam, Johanna H Meijer
Feb 6, 2020·Journal of Biological Rhythms·Danilo E F L Flôres, Gisele A Oda
Apr 16, 2021·Biochemical Pharmacology·M PanagiotouT Deboer

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