Correlations among Diabetic Microvascular Complications: A Systematic Review and Meta-analysis

Scientific Reports
Jianqing LiPeirong Lu

Abstract

Early detection of diabetic microvascular complications is of great significance for disease prognosis. This systematic review and meta-analysis aimed to investigate the correlation among diabetic microvascular complications which may indicate the importance of screening for other complications in the presence of one disorder. PubMed, Embase, and the Cochrane Library were searched and a total of 26 cross-sectional studies met our inclusion criteria. Diabetic retinopathy (DR) had a proven risk association with diabetic kidney disease (DKD) [odds ratio (OR): 4.64, 95% confidence interval (CI): 2.47-8.75, p < 0.01], while DKD also related to DR (OR: 2.37, 95% CI: 1.79-3.15, p < 0.01). In addition, DR was associated with diabetic neuropathy (DN) (OR: 2.22, 95% CI: 1.70-2.90, p < 0.01), and DN was related to DR (OR: 1.73, 95% CI: 1.19-2.51, p < 0.01). However, the risk correlation between DKD and DN was not definite. Therefore, regular screening for the other two microvascular complications in the case of one complication makes sense, especially for patients with DR. The secondary results presented some physical conditions and comorbidities which were correlated with these three complications and thus should be paid more attention.

References

Apr 1, 1992·Diabetes Care·D S BellB T Williams
May 10, 2002·International Ophthalmology·A M El-AsrarD Kangave
Aug 15, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C BoelterM J Azevedo
Jun 19, 2007·BMC Ophthalmology·Fatma Al-Maskari, Mohammed El-Sadig
Oct 19, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·H YokoyamaS Kanno
Feb 26, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·R PradeepaV Mohan
Mar 6, 2009·European Journal of Clinical Investigation·J JuradoJ M Pou
Mar 27, 2010·Revista da Associação Médica Brasileira·Ticiana C RodriguesMirela J Azevedo
Aug 17, 2010·Journal of Diabetes and Its Complications·Christina VoulgariNicholas Tentolouris
Feb 4, 2012·Diabetes Care·Joanne W Y YauUNKNOWN Meta-Analysis for Eye Disease (META-EYE) Study Group
Mar 1, 2012·Diabetes Care·Jie DingTien Yin Wong
Apr 24, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·J C WonB Y Cha
Jul 31, 2012·International Journal of Endocrinology·Bin-Bin HeWei-Ping Jia
Jun 8, 2014·The Journal of Physiology·Carmen Mora-FernándezJuan F Navarro-González
Sep 11, 2014·Investigative Ophthalmology & Visual Science·Won June LeeHeeyoon Cho
Oct 29, 2014·The Journal of Endocrinology·Yan Ding, Mary E Choi
Aug 25, 2015·Progress in Retinal and Eye Research·Alan W StittNoemi Lois
Sep 1, 2015·International Journal of Evidence-based Healthcare·Zachary MunnCatalin Tufanaru
Apr 16, 2016·Nature Reviews. Endocrinology·Ranjit UnnikrishnanViswanathan Mohan
Dec 21, 2016·The American Journal of Tropical Medicine and Hygiene·Pasipanodya Ian MachinguraExnevia Gomo
Sep 1, 2017·The British Journal of Ophthalmology·Guihua ZhangMingzhi Zhang
Sep 13, 2017·Journal of Diabetes and Its Complications·Anastasios TentolourisNikolaos Tentolouris
Mar 3, 2018·Diabetes Research and Clinical Practice·N H ChoB Malanda

❮ Previous
Next ❯

Citations

Jun 27, 2019·International Journal of Environmental Research and Public Health·Wiriya MahikulGraham F Medley
Oct 18, 2020·Diabetes Research and Clinical Practice·Danyelle Lorrane Carneiro VelosoAngelica Amorim Amato
Aug 15, 2021·Scientific Reports·Chul-Hyun ParkDon-Kyu Kim

❮ Previous
Next ❯

Software Mentioned

Stata
Review Manager ( RevMan )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.