Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats

Pharmacopsychiatry
A SartoriusP Gass

Abstract

The neurotrophin brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are a central part of the molecular concepts on neuroplastic changes associated with stress, anxiety and depression. An increasing number of studies uses serum BDNF levels as a potential indicator for central nervous system alterations. To analyze the relationship between brain tissue and serum BDNF and NGF levels, we used electroconvulsive shocks (ECS), an animal model of electroconvulsive therapy, and studied the temporal profile of neurotrophin expression in the hippocampus, prefrontal cortex and serum. 88 male Sprague-Dawley rats received single or serial ECS treatments and were killed between 3 hours and 14 days after the last treatment. We found a 2.8-fold rise for BDNF (1.3-fold for NGF) in the prefrontal cortex, and a 2.2-fold rise (1.2-fold for NGF) in the hippocampus after 5 ECS sessions. The temporal expression profile and correlation analyses between tissue and serum BDNF indicate that BDNF crosses the blood-brain barrier. No such correlation was found for NGF. The time course of central and peripheral BDNF changes may significantly differ. However, we demonstrate substantial evidence that it can be justified to measure serum BDN...Continue Reading

Citations

Feb 4, 2011·European Archives of Psychiatry and Clinical Neuroscience·Alessandra MinelliLuisella Bocchio-Chiavetto
Oct 22, 2010·Current Psychiatry Reports·Andrew F LeuchterBarry D Lebowitz
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francis E LotrichRobert E Ferrell
Oct 23, 2013·PloS One·Maria GieseAnne Eckert
Apr 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kirk I EricksonArthur F Kramer
Jan 15, 2014·Occupational and Environmental Medicine·Yunfeng ZouXiaobo Yang
Feb 25, 2014·Translational Neurodegeneration·Danielle K MurrayA Jon Stoessl
Sep 13, 2013·Pharmacogenomics·Olli Kampman, Esa Leinonen
Dec 8, 2010·Biomarkers in Medicine·Antonio Lucio TeixeiraArthur Kummer
Feb 13, 2013·Molecular Psychiatry·M GieseA Eckert
Jun 27, 2014·Neural Plasticity·Peter RotheneichnerSebastien Couillard-Despres
Apr 30, 2014·Acta Biochimica Et Biophysica Sinica·Ming He, Jikun Wang
Aug 13, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ali AmiriZahra Atrkar Roushan
Aug 3, 2012·European Addiction Research·Olga GeiselChristian A Müller
Dec 18, 2013·Journal of Psychiatry & Neuroscience : JPN·Thiago W ViolaRodrigo Grassi-Oliveira
Aug 21, 2012·Neurochemical Research·Jerzy A ZoladzGrzegorz Bartosz
Jan 14, 2016·Annals of Medicine·Karen SchmittAnne Eckert
Oct 9, 2012·Metabolism: Clinical and Experimental·Christian L RothThomas Reinehr
Jun 12, 2012·Journal of Psychiatric Research·Betina ElfvingOle Mors
Jan 23, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Alexander SartoriusGabriele Ende
Jan 17, 2012·Hormones and Behavior·Richard P EbsteinPoh San Lai
Nov 30, 2010·Pharmacology, Biochemistry, and Behavior·Cliona M O'MahonyJohn F Cryan
Aug 13, 2010·Psychoneuroendocrinology·B A A BusR C Oude Voshaar
Aug 24, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kai-Ren LuoShih-Jen Tsai
Jan 26, 2010·Schizophrenia Research·Ripu D JindalMatcheri S Keshavan
Apr 5, 2012·IUBMB Life·Michiko NakazatoMasaomi Iyo
Aug 19, 2011·Alcoholism, Clinical and Experimental Research·Marie-Agnès CostaDominique Malauzat
Aug 9, 2011·Scandinavian Journal of Medicine & Science in Sports·J BaggeS Forsgren

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