PMID: 9637626Jun 24, 1998Paper

Correlations between brain tissue oxygen tension, carbon dioxide tension, pH, and cerebral blood flow--a better way of monitoring the severely injured brain?

Surgical Neurology
E M DoppenbergH F Young

Abstract

The ideal method for monitoring the acutely injured brain would measure substrate delivery and brain function continuously, quantitatively, and sensitively. We have tested the hypothesis that brain PO2, pCO2, and pH, which can now be measured continuously using a single sensor, are valid indicators of regional cerebral blood flow (CBF) and oxidative metabolism, by measuring its product, brain pCO2. Twenty-five patients (Glasgow Coma Score < or = 8) were studied. A Clark electrode, combined with a fiber optic system (Paratrend 7, Biomedical Sensors, Malvern, PA) was used to measure intraparenchymal brain PO2, pCO2, and pH. Data were averaged over a 1-h period before and after CBF studies. Regional CBF was measured around the probe, using stable xenon computed tomography. Regression analyses and Spearman Rank tests were used for data analysis. Regional CBF and mean brain PO2 were strongly correlated (r=0.74, p=0.0001). CBF values < 18 mL/100 g/min were all accompanied by brain PO2 < or = 26 mm Hg. The four patients with a brain PO2 < 18 mm Hg died. Brain pCO2 and pH, however, were not correlated with CBF (r=0.36, p=0.24 and r=0.30, p=0.43, respectively). Until recently, substrate supply to the severely injured brain could only be...Continue Reading

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Citations

Mar 29, 2005·European Journal of Pharmacology·Penny D RihaF Gonzalez-Lima
May 27, 2003·British Journal of Anaesthesia·A J JohnstonD K Menon
Jul 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·N StocchettiE R Zanier
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May 27, 2006·Critical Care Nursing Clinics of North America·Mary Kay Bader
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Sep 13, 2006·Vertex : revista argentina de psiquiatriá·Hugo Hirsch

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