Correlations between fibrinolytic function and acute myocardial infarction

The American Journal of Cardiology
B Wiman, A Hamsten

Abstract

The diurnal variation of tissue plasminogen activator and plasminogen activator inhibitor--2 important factors in regulation of fibrinolysis--is well established, but its clinical implications are not yet fully understood. Fibrinolytic function was measured in a group of 133 patients less than 45 years of age, 3 months after they presented with myocardial infarction, and they were compared with an equal group of carefully matched control subjects. A sub-sample of 71 patients and 50 control subjects was examined 3 years later. Tissue plasminogen activator inhibitor plasma levels were higher in patients versus control subjects at 3 months and at 3 years after myocardial infarction, with a high degree of correlation between the 2 determinations (r = 0.87). Of all hemostatic parameters studied, only low tissue plasminogen activator activity and increased tissue plasminogen activator inhibitor levels were significantly different between patients with and without recurrent infarction during the 3-year period. In those patients with a second infarction greater than 3 years later, however, tissue plasminogen activator inhibitor concentration was not significantly related to reinfarction.

Citations

May 16, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Roy F M van der PuttenWim Th Hermens
Jun 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·B FernhallC M Kessler
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