Correlations between intestinal innate immune genes and cecal microbiota highlight potential for probiotic development for immune modulation in poultry

Applied Microbiology and Biotechnology
Nicky-Lee WillsonRebecca E A Forder

Abstract

Immune function is influenced by the diversity and stability of the intestinal microbiota. A likely trade-off of immune function for growth has been demonstrated in heavier breeds of poultry that have been genetically selected for growth and feed efficiency traits. We investigated the expression of selected innate immune genes and genes encoding products involved in intestinal barrier function to determine whether function changes could be consistently linked to the phenotypic expression of feed conversion ratio (FCR), a common measure of performance within poultry broiler flocks. In addition, we compared individual cecal microbial composition with innate immune gene expression. Samples were utilised from two replicate trials termed P1E1 and P1E2. High (n = 12) and low (n = 12) performing birds were selected based on their individual FCR data from each replicate and combined for microbiota phylogenetic composition and immune gene expression analysis. Toll-like receptor 1 (TLR1La) and zonula occludens 1 (ZO1) were differentially expressed between high- and low-performing broilers. Several taxa were correlated with FCR; of these, unclassified YS2 and ZO1 were also positively correlated with each other. Interactions between taxa a...Continue Reading

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Citations

Jan 16, 2020·Animals : an Open Access Journal From MDPI·Ivan Rychlik
Jan 9, 2021·Frontiers in Microbiology·Wenjun DengSteven C Ricke
Jun 14, 2021·Food Microbiology·M MarmionA G M Scannell

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Methods Mentioned

BETA
electrophoresis
PCR
454 sequencing

Software Mentioned

Blast
Pintail
PyroBayes
Ensembl
SDS
NormFinder
QIIME
Ensembl browser
Calypso
RAST

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