Correlations between metabolic texture features, genetic heterogeneity, and mutation burden in patients with lung cancer

European Journal of Nuclear Medicine and Molecular Imaging
Seung Hwan MoonSe-Hoon Lee

Abstract

This study investigated the correlations between parameters of 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) scan and indices of genetic properties, heterogeneity index (HI), and tumor mutation burden (TMB), in patients with lung cancer. We produced 106 PET indices for each tumor site that underwent genomic analysis in a total of 176 study subjects (age, 62.0 ± 10.0 y; males, 68.2%), comprising 101 adenocarcinoma (ADC), 29 squamous cell carcinoma (SQCC), and 46 small cell lung cancer (SCLC) patients. We then examined the correlations of the PET parameters with genetic properties of HI and TMB, according to pathology and tumor site. Comparisons between PET parameters and the genetic properties with false discovery rate (FDR) correction revealed that the surface standard uptake value (SUV) entropy of SUV statistics had a significant correlation with HI only in patients with SCLC who underwent a genetic test in lymph nodes (r = 0.592, p = 0.028), whereas PET parameters did not show a significant correlation with HI or TMB in patients with SCLC who underwent a genetic test in lung tissue. In patients with ADC and SQCC, there was no significant correlation between PET parameters and the genetic properties...Continue Reading

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Citations

Jul 10, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Marius E MayerhoeferHeiko Schöder
Jun 26, 2020·Nuclear Medicine and Molecular Imaging·Yong-Jin ParkSeung Hwan Moon
Jun 14, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Gary J R Cook, Vicky Goh
Mar 16, 2019·Scientific Reports·Bo Young OhWoong-Yang Park
Mar 27, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Kerstin ClasenDaniela Thorwarth
Jul 23, 2020·Journal of Computer Assisted Tomography·Colin Y WangDaniel T Ginat
Nov 29, 2020·European Radiology·Manuel Piñeiro-FielPablo Aguiar
Jul 8, 2020·Methods : a Companion to Methods in Enzymology·Marius E MayerhoeferHeiko Schöder
Mar 7, 2021·Diagnostics·Manuel Piñeiro-FielPablo Aguiar

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