Correlations between water maze performance and cortical somatostatin mRNA and high-affinity binding sites during ageing in rats

The European Journal of Neuroscience
P DournaudJ Epelbaum

Abstract

Somatostatin levels and high-affinity (somatostatin-1) binding sites are decreased in post-mortem cortical samples of Alzheimer's disease patients but the relationships between such modifications and the cognitive deficits remain to be established. We investigated these relationships in the ageing rat. Three age groups (3-4, 14-15 and 26-27 months) were tested in a modified version of the Morris water maze. Somatostatin mRNA levels were quantified by in situ hybridization and somatostatin binding sites by radioautography using the selective agonist octreotide (SMS 201995) as a competing drug to evaluate high-affinity (somatostatin-1) and low-affinity (somatostatin-2) binding sites. The number of somatostatin mRNA-containing cells was not modified with age or memory performance in cortical, hippocampal and hypothalamic regions, but somatostatin mRNA densities were significantly decreased with age and with memory performance in the frontal and parietal cortex. In the frontal cortex somatostatin mRNA densities were already decreased in 14- to 15-month-old rats, whereas the decrease was observed only in 26- to 27-month-old rats in the parietal cortex. A decrease in somatostatin-1 binding was observed with memory performance, indepe...Continue Reading

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Citations

Mar 24, 2004·Trends in Neurosciences·Scott C Baraban, Melanie K Tallent
Mar 4, 2000·Brain Research·M Sánchez-AlavezO Prospéro-García
Nov 23, 2000·Journal of Physiology, Paris·C ViolletJ Epelbaum
Apr 1, 2008·Neuroscience Letters·Abdeslem El Idrissi
May 22, 2009·Journal of Neurochemistry·Jana Sánchez-WandelmerRebeca Busto
Jul 18, 2006·Neurobiology of Aging·David Aguado-LleraVicente Barrios
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A BeaudetH Boudin
Nov 11, 2017·Molecular & Cellular Proteomics : MCP·Vivian DelcourtIsabelle Fournier
Nov 25, 2004·Endocrine Reviews·Roy G SmithYuxiang Sun

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