Correlations of placental perfusion and PlGF protein expression in early human pregnancy

American Journal of Obstetrics and Gynecology
Paul C WelchDonald S Torry

Abstract

The purpose of this study was to investigate temporal correlations between maternal serum placenta growth factor levels and placental perfusion in early human pregnancies. Systolic umbilical artery Doppler blood flow velocity indices at fetal and placental insertion sites were measured between 7 and 22 weeks of gestation from normal singleton pregnancies. Maternal serum placenta growth factor levels were determined by enzyme-linked immunosorbent assay. Maternal serum placenta growth factor levels showed an exponential increase at approximately 14 weeks of gestation. Placenta perfusion, as estimated by systolic Doppler blood flow indices, significantly increased with gestational age (P < .0001). There was a close association between placenta growth factor expression levels and evidence of increased placenta perfusion (P < .033). The significant increase in serum placenta growth factor coincides with the increased perfusion of the maternal/fetal interface at approximately 12 to 14 weeks of gestation. Correlation of placenta growth factor expression and placental perfusion suggests that placenta growth factor may contribute to assuring adequate vascular development/function of the placenta early in gestation.

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Citations

Jul 10, 2007·Journal of Assisted Reproduction and Genetics·Donald S TorryRonald J Torry
Nov 14, 2007·American Journal of Reproductive Immunology : AJRI·Jocelyn M WesselsChandrakant Tayade
Feb 19, 2008·Clinics in Perinatology·Cande V Ananth, Anthony M Vintzileos
Nov 8, 2011·American Journal of Obstetrics and Gynecology·Samantha J BentonPeter von Dadelszen
Dec 30, 2014·Biology of Reproduction·Kristiina L AasaB Anne Croy
Apr 20, 2016·Hypertension·Lucinda M Hilliard, Kate M Denton
Feb 12, 2008·Prenatal Diagnosis·George MakrydimasKypros H Nicolaides
Aug 21, 2019·The American Journal of Pathology·Lyda WilliamsMaureen J Charron

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