Correlations of serum cystatin C level and gene polymorphism with vascular cognitive impairment after acute cerebral infarction

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Qiong ZengKun Lin

Abstract

The aim of this study was to explore the possible correlations of serum cystatin C level and cystatin C gene (CST3) polymorphism with vascular cognitive impairment in patients who had acute cerebral infarction. A total of 152 patients with acute cerebral infarction were recruited in this case-control study. Patients were divided into vascular cognitive impairment (VCI) group (n = 71) and cognitive impairment no dementia (CIND) group (n = 81). The serum concentrations of cystatin C were measured with immunoturbidimetric assay while the gene polymorphisms of CST3 were determined by technique polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In the VCI group, serum cystatin C level was significantly higher than that in the control group. The frequency of the B allele was found to be higher in the VCI group as compared with that of the CIND group (18.5% vs 7.7%, p = 0.006). In logistic regression analysis, significant associations of VCI with high serum cystatin C level (OR 3.837 (1.176-12.520), p = 0.026) and CST3 B allele (OR 2.038 (1.048-3.963), p = 0.036) were also found. A high cystatin C level and CST3 B allele confer risks for VCI after acute cerebral infarction. It is probable that measurement o...Continue Reading

References

Apr 19, 2000·Acta Neurologica Scandinavica·J KálmánZ Janka
Feb 24, 2001·Journal of Neuropathology and Experimental Neurology·E LevyF Tagliavini
Sep 11, 2001·The American Journal of Pathology·A DengG W Rebeck
May 22, 2003·Neurobiology of Disease·Luisa BenussiGiuliano Binetti
Jun 24, 2004·Neurobiology of Aging·Magdalena SastreEfrat Levy
Sep 1, 2005·Journal of Alzheimer's Disease : JAD·Roberto MonasteroRosolino Camarda
Feb 21, 2007·Dementia and Geriatric Cognitive Disorders·Liang-Jen ChuoYu-Min Kuo
Nov 21, 2007·Nature Genetics·Stephan A KaeserMathias Jucker
May 7, 2008·Expert Review of Neurotherapeutics·Efrat Levy
May 23, 2008·Annals of Neurology·Kristine YaffeManjula Kurella-Tamura
Oct 1, 2008·Neurology·J SundelöfL Lannfelt
Apr 22, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Eva Zerovnik
Feb 17, 2010·Journal of Alzheimer's Disease : JAD·Belen TizonEfrat Levy
Sep 23, 2010·Journal of Alzheimer's Disease : JAD·Roberta GhidoniGiuliano Binetti
Mar 23, 2012·The International Journal of Neuroscience·Ye HuaHuihan Jin
Apr 11, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fredrik StrålbergUlf H Lerner
Nov 5, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yelena SlininUNKNOWN Study of Osteoporotic Fractures
Sep 24, 2016·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Wei-Dong HuChun-Feng Liu
Dec 21, 2016·Journal of the American Geriatrics Society·Ke-Liang ChenQi-Hao Guo
Jan 31, 2017·Journal of the Neurological Sciences·Stefano DiciottiUNKNOWN VMCI Tuscany investigators
Mar 23, 2017·Journal of the Neurological Sciences·Yudan WeiJianmin Zhu

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Citations

Aug 20, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Chen ZhuCheng Zhan
Mar 29, 2020·Journal of Molecular Neuroscience : MN·Xinxin Zhang, Xia Bi
May 27, 2021·Genetic Testing and Molecular Biomarkers·Jeneffar Roselin ChristopherAnupama Tadepalli
Oct 20, 2020·Dementia and Geriatric Cognitive Disorders·Pallavi NairPradeep Kumar

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