Correlative analysis of overall survival with clinical characteristics in 127 patients with mantle cell lymphoma: a multi-institutional cohort in Taiwan

International Journal of Hematology
Yu-Hung WangTai-Chung Huang

Abstract

Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma often with extranodal involvement at diagnosis, and yet how this feature correlates with survival awaits elucidation. To address this issue, a correlative analysis between clinical features of 127 MCL patients and their overall survival (OS) was conducted. In this cohort, the median age at MCL diagnosis was 62 years and 81% were males. Eighty-four percent of patients were Ann Arbor stage 4, and 15% were blastoid variants. In patients with gastrointestinal MCL, approximately 40% had gastric involvement. In treatment, CHOP-based induction chemotherapy was given to 61.1% of patients. One-third of patients undertook autologous stem cell transplant (SCT), and 4.7% had allogeneic SCT. The median OS was 82 months and well-stratified in MIPI risk groups. In the multivariate analysis for OS, blastoid variants and gastric involvement were both independent risk factors whereas auto-SCT had a protective effect. Overall, this study corroborated with the current understandings and international therapeutic standards for MCL. Auto-SCT associated with a better OS while allo-SCT remained an option for blastoid variants and those who failed Auto-SCT. Interestingly, patients with gastric...Continue Reading

References

Feb 1, 1989·British Journal of Cancer·R A CowanD Crowther
Oct 1, 1982·European Journal of Cancer & Clinical Oncology·L EndrizziV Fosser
Mar 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W MillsA H Goldstone
Mar 1, 1994·Radiographics : a Review Publication of the Radiological Society of North America, Inc·L S RabushkaE K Fishman
Dec 3, 1999·British Journal of Haematology·D P Steensma, T E Witzig
Feb 24, 2001·European Radiology·F RobertsonO Ekberg
Jun 28, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N G MikhaeelA R Timothy
Sep 8, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jorge E RomagueraFernando F Cabanillas
Sep 27, 2006·The American Journal of Surgical Pathology·Antonio SalarSergio Serrano
Mar 21, 2007·Seminars in Ultrasound, CT, and MR·Kunwar BhatiaRodney H Reznek
Oct 27, 2007·Blood·Eva HosterUNKNOWN European Mantle Cell Lymphoma Network
Nov 21, 2007·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Nuno Pinto LeiteClaude B Sirlin
Aug 12, 2009·Journal of Hematopathology·Wolfram KlapperUNKNOWN European MCL Network
May 28, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Sally F BarringtonMichael J O'Doherty
Nov 19, 2011·The British Journal of Radiology·S S SabooJ P Jagannathan
May 9, 2012·Hematology Reports·Duska PetranovicNives Jonjic
Aug 2, 2012·Archives of Pathology & Laboratory Medicine·Lauren B Smith, Scott R Owens
Nov 2, 2012·The New England Journal of Medicine·Yukie TakahashiTetsuya Tanimoto
Feb 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carlo ViscoFrancesco Rodeghiero
Dec 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy S FenskeParameswaran N Hari
May 8, 2014·World Journal of Gastroenterology : WJG·Makoto SaitoEriko Tsukamoto
Dec 22, 2014·Cancer Letters·Katarzyna AugoffRenata Tabola
Mar 5, 2015·The New England Journal of Medicine·Tadeusz RobakUNKNOWN LYM-3002 Investigators
Nov 5, 2015·The New England Journal of Medicine·Jia RuanJohn P Leonard
Feb 24, 2016·The Lancet Oncology·Marek TrněnýUNKNOWN SPRINT trial investigators and in collaboration with the European Mantle Cell Lymphoma Network
Dec 9, 2016·The Lancet. Haematology·Andrew Lipsky, Peter Martin
Dec 19, 2018·British Journal of Haematology·Simon RuleKarl S Peggs

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.