Abstract
The spontaneously hypertensive rat model has been used to show that hypertension is an important pathophysiological risk factor in age-related hearing loss. In the present study, compound action potential (CAP), electrochemical potential (ECP), and potassium concentration (CK+) measurements were taken from the cochlea of genetically predisposed, spontaneously hypertensive rats (SHR) and from normotensive Wistar-Kyoto (WKY) rats. In the SHR model, as the duration of hypertension increased with the animal's age (from 3 to 8 months), CAP thresholds increased, ECP increased in marginal cells only, and CK+ increased in both endolymph and marginal cells. Collectively, the data suggest that ionic alternations of cellular potentials are involved in hearing changes in the hypertensive state. Ultimately, such data may assist in understanding hearing loss in individuals who are diagnosed with hypertension.
References
Jan 1, 1986·Journal of Cardiovascular Pharmacology·L C Garg, N Narang
Mar 1, 1989·Hearing Research·W S QuirkJ W Wright
Aug 1, 1989·Hearing Research·W S QuirkJ W Wright
Jan 1, 1985·Hearing Research·H A DengerinkP Goodwin
Jan 1, 1987·Hearing Research·M Hillerdal
May 1, 1988·Hearing Research·W S QuirkJ M Miller
Sep 1, 1987·Acta Oto-laryngologica·M HillerdalE Hultcrantz
Jan 1, 1985·Hearing Research·J W WrightP C Goodwin
Jan 1, 1981·Acta Oto-laryngologica. Supplementum·E Borg
Mar 1, 1984·Acta Oto-laryngologica·M TachibanaO Mizukoshi
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J G McCormickR B Lassiter
Oct 1, 1982·Hearing Research·E Borg
Oct 1, 1982·Hearing Research·E Borg
Mar 1, 1981·Circulation Research·N C Trippodo, E D Frohlich
Jan 13, 1995·European Journal of Pharmacology·I Sahin-ErdemliE Songu-Mize
Nov 1, 1994·Hypertension·R W GurichC R Caflisch
Nov 1, 1995·Hearing Research·Y L MaK E Rarey
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI
Jan 1, 1962·Transactions of the American Otological Society·S ROSENM HAMAD SATTI
Sep 1, 1962·The Annals of Otology, Rhinology, and Laryngology·S ROSENM H SATTI
Citations
Oct 7, 2003·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Sui LiQingsong Yu
Dec 1, 2009·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·T Y TanR Raman
Jan 16, 2014·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Saurabh AgarwalSmita K Nagle
Mar 10, 2004·Pharmacology, Biochemistry, and Behavior·Sherry A Ferguson, Amy M Cada
Dec 22, 2000·Hearing Research·I MosnierE Ferrary
Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·L Lippincott, K E Rarey
Feb 25, 2009·The Laryngoscope·David R FriedlandSergey Tarima
Jun 3, 2015·Blood Pressure·Tomasz PrzewoźnyKrzysztof Narkiewicz
Dec 31, 2014·PloS One·In-Hwan OhSeung Geun Yeo
Jan 22, 2019·BioMed Research International·Boshen WangJuan Zhang
Dec 18, 2020·Acta Oto-laryngologica·Arzu Kirbac, Bilgehan Boke