PMID: 6112217Jan 1, 1981Paper

Correlative immunocytochemical and electron microscopic studies: identification of (entero)glucagon- somatostatin- and pancreatic polypeptide-like-containing cells in the human colon

Histochemistry
T LehyM L Cristina

Abstract

Correlative immunocytochemical and electron microscopic studies, using the semi thin-thin technic, were performed to identify the (entero) glucagon, somatostatin and pancreatic polypeptide-like immunoreactive cells of the human colonic mucosa. Mean granule diameter for each cell type was estimated according to two methods and histograms showing the granule size distribution were constructed. A total of 139 immunostained cells identified at the ultrastructural level were analyzed. Mean granule diameter for (entero)glucagon-containing cells was 318 +/- 11 nm but a reduction of granule size with age was noteworthy: granules were larger in the fetus (mean diameter 350 +/- 15) than in adults (mean diameter 310 +/- 10 nm). Somatostatin-containing cells, very rare in adults, were present in the fetal distal colon. Their general mean granule diameter was 354 +/- 18 nm but many cells had a mean granule diameter of more than 400 nm. A pancreatic polypeptide-like immunoreactivity was found only in (entero)glucagon-containing cells, pointing out the possible occurrence of both peptides (or of similar sequences) in the same cells. Previous ultrastructural studies dealing with a tentative classification of the human colonic endocrine cells w...Continue Reading

References

Apr 17, 1978·Virchows Archiv. A, Pathological Anatomy and Histology·M L CristinaS Bonfils
Dec 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M H GreiderR L Gingerich
Sep 5, 1978·Cell and Tissue Research·R BuffaE Solcia
May 1, 1976·The Journal of Cell Biology·D BaetensL Orci
Apr 1, 1977·The Journal of Clinical Endocrinology and Metabolism·B H BergstromK H Gabbay
Jul 1, 1977·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R C McEvoyR P Elde
Aug 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J P PetraliL A Sternberger
Oct 1, 1974·Journal of Clinical Pathology·J Piris, R Whitehead
Sep 1, 1965·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B P Lane, D L Europa
Jan 1, 1971·Scandinavian Journal of Gastroenterology·J M PolakA G Pearse

❮ Previous
Next ❯

Citations

Feb 1, 1995·Cell and Tissue Research·T Trandaburu, F Nürnberger
Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·Y TsutsumiN Yanaihara
Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·Y TsutsumiN Yanaihara
Aug 1, 1989·Digestive Diseases and Sciences·J CalamS R Bloom
Mar 1, 1988·Diseases of the Colon and Rectum·T R KochV L Go
Jan 1, 1985·Acta histochemica·G E FeurleV Helmstädter
Jun 14, 2013·The Journal of Veterinary Medical Science·Kei NishimuraTakafumi Watanabe
Jan 1, 1996·Scandinavian Journal of Gastroenterology·M El-Salhy, O Suhr
Jan 1, 1985·Progress in Histochemistry and Cytochemistry·J A Litwin
Jul 1, 1987·Cell and Tissue Research·R JärviA Hervonen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.