Correlative study between C-reactive protein, clinical severity, and nerve conduction studies in Guillain-Barrè syndrome

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Yosria A AltaweelShimaa AbdelBadea

Abstract

Guillain-Barre' syndrome (GBS) is a serious autoimmune disorder in which the immune system attacks healthy nerve cells of the peripheral nervous system causing polyradiculoneuropathy which leads to weakness, numbness, and tingling, and can eventually cause paralysis. Autoimmune conditions like GBS can induce a high level of inflammation resulting in an increase in the C-reactive protein( CRP) production. The aim of this study is to assess the relationship between CRP level and the clinical severity as well as the electrophysiological findings of nerve conduction studies in patients with GBS. Twenty- four patients (10 males &14 females) with ages ranged from 14 to 50 years and a mean age of 33.46 ±12.25 years who fulfilled the clinical criteria for diagnosing GBS were recruited within the first 2 weeks of onset of illness, in a cross- section study. They underwent general and neurological examination. Nerve conduction studies as well as assessment of serum CRP level were done. There was a statistically significant positive correlation between clinical severity assessed by (Hughes disability scale) and serum CRP level in GBS patients. Multivariate logistic regression analysis showed that both gastroenteritis, cranio-bulbar affect...Continue Reading

References

Jan 1, 1990·Annals of Neurology·A K Asbury, D R Cornblath
Jul 1, 1997·American Journal of Obstetrics and Gynecology·A M PeacemanM Pietrantoni
Dec 13, 1997·The Journal of Infectious Diseases·R A Hughes, J H Rees
Dec 14, 1999·The Journal of Emergency Medicine·B Clyne, J S Olshaker
Jun 19, 2001·Archives of Neurology·P H Gordon, A J Wilbourn
Apr 12, 2003·Neurology·A ChiòUNKNOWN Piemonte and Valle d'Aosta Register for Guillain-Barré Syndrome
Nov 24, 2004·Clinical & Developmental Immunology·Alexander J Szalai
Jan 18, 2005·American Journal of Physiology. Heart and Circulatory Physiology·David C W LauSubodh Verma
Jun 17, 2005·Journal of the Peripheral Nervous System : JPNS·Hugh J Willison
Nov 8, 2005·Lancet·Richard A C Hughes, David R Cornblath
Jun 20, 2007·Disability and Rehabilitation·Fernando Ortiz-CorredorJorge Díaz-Ruíz
Mar 23, 2011·Neuroepidemiology·James J SejvarOliver W Morgan
Apr 7, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Antonino Uncini, Satoshi Kuwabara
May 9, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Yusuf A Rajabally, Antonino Uncini
Jun 15, 2012·The New England Journal of Medicine·Nobuhiro Yuki, Hans-Peter Hartung
Jun 27, 2012·Critical Care : the Official Journal of the Critical Care Forum·Suzana Margareth Lobo
Oct 29, 2013·Brain : a Journal of Neurology·Christiaan FokkeBart Casper Jacobs
Jan 25, 2014·Journal of the Peripheral Nervous System : JPNS·Jayantee KalitaMoromi Das
Apr 18, 2014·Indian Journal of Pathology & Microbiology·Chetana VaishnaviSudesh Prabhakar

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Citations

Nov 29, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Pingping NingYanming Xu

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Software Mentioned

Galileo NT
Statistical Package of Social Science ( SPSS

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