Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sjögren syndrome

Rheumatology International
Donato RiganteMassimo Castagnola

Abstract

The aberrant induction of salivary/lacrimal proteins is considered to be crucial in the pathogenesis of sicca-symptoms related to primary Sjögren syndrome (SS). We report the case of an 11-year-old boy who was admitted to hospital due to recurrent bilateral parotid gland enlargement and keratoconjunctivitis, which were diagnosed as primary SS upon a combination of laboratory and instrumental tests. The proteomic analysis of the salivary peptide complex in the patient's salivary fluid near diagnosis and after 6 months of pharmacological therapy revealed quantitative and mostly qualitative differences. This observation reveals that clinical and functional changes of the salivary glands driven by non-steroidal antinflammatory drugs might be reflected in different proteomic patterns of the salivary fluid.

References

Apr 25, 1992·British Dental Journal·W M Edgar
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M S Lamkin, F G Oppenheim
Aug 1, 1996·European Journal of Oral Sciences·E C VeermanA V Nieuw Amerongen
May 1, 1997·Annals of the Rheumatic Diseases·A A DrososA Siamopoulou-Mavridou
Jun 10, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·I Al-HashimiP C Fox
Feb 6, 2002·Free Radical Biology & Medicine·Rafael M NaglerAbraham Z Reznick
Apr 9, 2002·Oral Diseases·A V Nieuw Amerongen, E C I Veerman
Jun 10, 2003·Clinical Reviews in Allergy & Immunology·Andrea T BorchersM Eric Gershwin
Aug 5, 2003·European Journal of Pediatrics·Rolando CimazAlexandros A Drosos
Aug 16, 2005·Expert Review of Proteomics·Francisco Manuel Lemos AmadoJosé Alberto Ramos Duarte
Mar 8, 2007·Journal of Proteome Research·Rosanna InzitariMassimo Castagnola

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Citations

Oct 27, 2010·Expert Review of Proteomics·Francisco AmadoRui Vitorino
Oct 3, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Massimo CastagnolaIrene Messana
Dec 3, 2020·Seminars in Arthritis and Rheumatism·Achille MarinoRolando Cimaz

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