Correspondence between Helicobacter pylori antibodies and urea breath test results in a US-Mexico birth cohort

Paediatric and Perinatal Epidemiology
Zhannat NurgalievaBenjamin D Gold

Abstract

The uncertain accuracy of methods for detecting Helicobacter pylori infection in young children complicates research on this infection in early life. The aim of the present report was to describe the correspondence between positive serology and positive urea breath test (UBT) in children followed from age 0 to 24 months in the Pasitos Cohort Study, conducted along the US-Mexico border at El Paso and Juarez. Children were recruited before birth during 1998-2000 and examined at target ages of 6, 12, 18 and 24 months. H. pylori infection was detected using an enzyme immunoassay for serum immunoglobulin G antibodies and the (13)C-urea breath test corrected for age-dependent variation in CO(2) production. Of 472 children, 125 had one or more positive UBT results and 46 had one or more positive serology results. The prevalence of H. pylori infection at target ages of 6, 12, 18 and 24 months was 7%, 14%, 16% and 19%, respectively, by UBT and 8%, 2%, 3% and 3%, respectively, by serology. Few (<1%) of those tested on both tests were positive on both at any age. Among UBT-positive children, 6% were concurrently seropositive and 6% became seropositive later. Because UBT positivity cut points were selected to minimise false positives, thes...Continue Reading

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Citations

Apr 30, 2014·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Hamed Said HabibBasem Salama El-Deek
May 21, 2009·Pharmacoepidemiology and Drug Safety·Cheryl S BroussardCorinne C Aragaki
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Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Feb 17, 2009·Medicine, Health Care, and Philosophy·Andrew Ward

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