Correspondence between symptoms and preference-based health status measures in the STOP study

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
Laura S GoldLarry Kessler

Abstract

Pulmonary exacerbations (PEx) in cystic fibrosis (CF) patients decrease lung function, increase symptoms and reduce health-related quality of life (HRQoL). We evaluated associations between 8 symptom-based questions from the Cystic Fibrosis Respiratory Symptom Diary - Chronic Respiratory Infection Symptom Score (CFRSD-CRISS) and the 5-level EuroQOL-5 Dimensions (EQ-5D-5 L) summary score and hypothesized the CFRSD-CRISS would be well-correlated with quality-of-life measures among CF patients with PEx. CF patients who had CFRSD-CRISS and EQ-5D-5L measurements on the day of the initial PEx, 7 days later, and at the end of intravenous antibiotic treatment were included. We examined age-stratified (<18 versus ≥18 years old) characteristics, including the percent predicted of forced expiratory volume in 1 s (ppFEV1), CFRSD-CRISS measurements, and domains of the EQ-5D. We also calculated age-stratified Pearson correlation coefficients between the EQ-5D-5L and CFRSD-CRISS items at each of the 3 time points. A total of 169 patients were analyzed. Patients reported having problems performing usual activities and with pain/discomfort on the first day of the PEx and these measures improved by the end of treatment. PpFEV1 improved in both a...Continue Reading

References

Aug 9, 2001·Annals of Medicine·R Rabin, F de Charro
Apr 10, 2002·Journal of Health Economics·John BrazierMark Deverill
Mar 9, 2005·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Louise GeeA Kevin Webb
Aug 23, 2005·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Stephen J Walters, John E Brazier
Feb 15, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Salah AburuzLiam G Heaney
May 1, 2009·Lancet·Brian P O'Sullivan, Steven D Freedman
Jun 2, 2009·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·C H GossD L Patrick
Aug 22, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Richard NormanJulie Ratcliffe
Jul 28, 2012·The European Respiratory Journal·Judy M BradleyJ Stuart Elborn
Jun 9, 2014·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Ji Young HongYoung Ae Kang
Feb 3, 2015·Annals of the American Thoracic Society·Al-Rahim R HabibBradley S Quon
Apr 17, 2015·Health and Quality of Life Outcomes·Sarah AcasterAmanda Copans
Jun 5, 2015·PharmacoEconomics·Nalin PayakachatJ Mick Tilford
Jun 9, 2015·Annals of the American Thoracic Society·Michael S SchechterCori L Daines
Nov 1, 2014·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·C T SolemB Castiglione
Apr 26, 2017·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·D R VanDevanterUNKNOWN STOP Study Group
May 2, 2017·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Natalie E WestUNKNOWN STOP investigators
May 4, 2017·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Don B SandersUNKNOWN STOP Study Group
Feb 6, 2018·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Ruth H Keogh, Sanja Stanojevic

❮ Previous
Next ❯

Citations

May 6, 2019·PharmacoEconomics Open·Bishal MohindruJennifer A Whitty
May 28, 2019·Pediatric Pulmonology·Adrienne P Savant, Susanna A McColley
Aug 18, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·D R VanDevanterUNKNOWN STOP-OB Study
Mar 16, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Natalie FranzLarry G Kessler
May 28, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Laura S GoldLarry Kessler
Sep 2, 2021·American Journal of Respiratory and Critical Care Medicine·Christopher H GossUNKNOWN STOP2 Investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

CFTR Mutant Structural Therapy

Over 1700 different mutations in the CFTR genes have been shown to cause cystic fibrosis. Here is the latest research on structural therapy for CFTR mutants.

© 2022 Meta ULC. All rights reserved