PMID: 9554251Apr 29, 1998Paper

Corrosion behavior of copper in a copper bearing intrauterine device in the presence of indomethacin

Contraception
H XueC Zhang

Abstract

As an improvement to the use of the copper bearing intrauterine device, indomethacin has been introduced to reduce the incidence of bleeding after insertion of the device. The effects of indomethacin on copper corrosion were studied in vitro in simulated uterine fluid. Electrochemical polarization resistance measurements indicated that indomethacin powder slightly increased the corrosion rate of copper if pH of the fluid was not under control and it did not change the corrosion rate if pH was adjusted daily to maintain some constancy. The experimental results for medication by indomethacin-releasing Silastic were basically the same as those with powdered indomethacin. X-ray diffraction showed that only cuprous oxide was formed on the copper substrated surface and that indomethacin did not affect the corrosion products. As scanning electron microscopy demonstrated, however, in the presence of indomethacin the oxide particles formed were found to be more coarse and dense than in the absence of indomethacin.

References

Sep 1, 1982·Contraception·M ThieryH J Tatum

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Citations

May 24, 2011·Journal of Materials Science. Materials in Medicine·Xianping XiaChanghong Zhu
May 16, 2009·Contraception·Juan LiLintao Jia
Jan 7, 2009·Colloids and Surfaces. B, Biointerfaces·Zhihong YangShuizhou Cai
Apr 26, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Xianping XiaChangsheng Xie
Aug 21, 2007·Contraception·Juan LiXiwang Wu
Sep 14, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Juan LiXiwang Wu
May 6, 2010·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Xiaowen ZhouJianping Liu
Jan 21, 2006·Colloids and Surfaces. B, Biointerfaces·Zhihong Yang, Changsheng Xie

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