Cortical abnormalities and their cognitive correlates in patients with temporal lobe epilepsy and interictal psychosis

Epilepsia
Leticia Gutierrez-GalveJacqueline Foong

Abstract

To determine whether cortical abnormalities are more severe and widespread in patients with temporal lobe epilepsy (TLE) and interictal psychosis (IP) compared to those with TLE only (NIP) and healthy controls (HC), and to explore the associations between cortical parameters (area, thickness and volume), psychotic symptoms, and cognitive performance. Twenty-two patients with IP (9 male; 10 hippocampal sclerosis, HS), 23 TLE nonpsychotic (NIP) patients (11 male; 13 HS) matched for duration of epilepsy and 20 HC participated. Surface-based morphometry (SBM) was used to measure cortical parameters. Cognition was examined in IP and NIP patients. Associations between cortical parameters and cognition were examined using linear mixed models adjusted by age, gender, and brain volume. IP patients had an earlier onset of epilepsy, more status epilepticus, and worse cognitive performance than NIP patients. In IP patients, cortical thickness was reduced in the inferior frontal gyrus (IFG), and their current IQ was associated with decreases in area, but not thickness, in regions of the frontotemporal cortex. IP likely reflects the interplay of psychosis-related genetic factors and the cumulative effects of seizure activity on the brain. Co...Continue Reading

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Citations

Nov 10, 2012·Therapeutic Advances in Neurological Disorders·Kousuke KanemotoTomohiro Oshima
Jun 28, 2014·Epilepsy & Behavior : E&B·Anna Rita Giovagnoli
Dec 24, 2017·Practical Neurology·Melissa MaguireAnthony Marson
Dec 25, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·James AlleboneSarah J Wilson
Jul 2, 2019·Epilepsia·Yamile Calle-LópezPeter Wolf
Jul 10, 2019·Neurological Research·Sherifa Ahmed Hamed, Fadia Ahmed Attiah
Jul 19, 2019·Therapeutic Advances in Psychopharmacology·Niruj Agrawal, Marco Mula

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