PMID: 9450608Feb 5, 1998Paper

Cortical acetylcholine and processing capacity: effects of cortical cholinergic deafferentation on crossmodal divided attention in rats

Brain Research. Cognitive Brain Research
J Turchi, M Sarter

Abstract

The effects of 192 IgG-saporin-induced lesions of the corticopetal cholinergic neurons of the basal forebrain on divided attention were assessed in rats. Divided attention was measured using an operant version of the crossmodal divided attention paradigm. This task utilized the propositional response rules of visual and auditory conditional discriminations. Presentation of only visual or only auditory stimuli constituted performance under the condition of modality certainty. Conversely, the presentation of a randomized sequence of all possible stimuli represented the condition of modality uncertainty and was hypothesized to tax processing capacity. A single session was composed of two unimodal blocks of trials (20 trials each), followed by a bimodal block of 60 trials. Animals were extensively trained in this task and baseline performance was characterized by high response accuracy (> 80%) in both conditions. Compared to unimodal trials, the response latencies in the bimodal block of trials were 160 ms longer. The lesion of the cholinergic system increased the response latencies exclusively under the condition of modality uncertainty. The extent of the lesion-induced decrease in cortical cholinergic fiber density correlated hig...Continue Reading

References

Nov 1, 1992·Journal of Clinical and Experimental Neuropsychology·J V FiloteoD P Salmon
Jan 1, 1992·Annual Review of Psychology·R A Kinchla
May 1, 1992·Neurobiology of Aging·E K PerryR H Perry
Jun 1, 1991·Electroencephalography and Clinical Neurophysiology·J HohnsbeinL Blanke
Nov 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H TagoT Maeda
May 1, 1988·Journal of Experimental Psychology. Human Perception and Performance·Joan M McDowd, Fergus I M Craik
May 1, 1971·Journal of Experimental Psychology·H G Shulman, S N Greenberg
Jan 1, 1967·Acta Psychologica·E Tulving, P H Lindsay
Feb 1, 1983·Journal of Neurochemistry·N R SimsA N Davison
Sep 1, 1981·Journal of Gerontology·R E Wright
Feb 1, 1995·Neuropsychologia·K T CiesielskiS D Handmaker
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·M I Posner
May 1, 1994·Neuroscience·S Hecker, M M Mesulam
Jan 1, 1994·Journal of Neuropathology and Experimental Neurology·A A BookJ B Schweitzer
Jun 1, 1996·Brain Research. Cognitive Brain Research·J L Muir
Feb 1, 1997·Brain Research. Brain Research Reviews·M Sarter, J P Bruno
May 1, 1962·British Journal of Psychology·D E BROADBENT, A HERON

❮ Previous
Next ❯

Citations

May 4, 2004·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·A E ButtP E Garraghty
Apr 28, 2004·Psychopharmacology·Simon N KatnerMichael A Taffe
Jul 17, 2013·Biochemical Pharmacology·Rogier B Poorthuis, Huibert D Mansvelder
May 5, 2001·Brain Research. Brain Research Reviews·M SarterJ P Bruno
Feb 1, 1997·Brain Research. Brain Research Reviews·M Sarter, J P Bruno
Oct 24, 2003·Brain and Cognition·Monicque M Lorist, Mattie Tops
Sep 7, 2000·Neurotoxicology and Teratology·P J BushnellD M Warburton
Oct 10, 2002·Neural Networks : the Official Journal of the International Neural Network Society·Angela J Yu, Peter Dayan
Nov 2, 2001·Brain Research. Cognitive Brain Research·A M HimmelheberJ P Bruno
May 14, 1999·Current Opinion in Neurobiology·M G Baxter, A A Chiba
Oct 3, 2003·Neurobiology of Learning and Memory·Martin SarterBen Givens
Oct 28, 2004·Behavioral Neuroscience·Vicente Martinez, Martin Sarter
Jul 30, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael E Hasselmo, Martin Sarter
Jul 9, 2002·The European Journal of Neuroscience·Martin Sarter, John P Bruno
Nov 15, 2006·Learning & Memory·Núria Boix-TrelisMargarita Martí-Nicolovius
Jul 23, 1999·Annals of the New York Academy of Sciences·L ZaborszkyI Kallo
Mar 6, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vinay ParikhMartin Sarter
Jul 2, 2014·Current Opinion in Neurobiology·Michael J Higley, Marina R Picciotto
Dec 29, 2009·Behavioural Brain Research·Patrick Anselme
Jun 17, 2008·Behavioural Processes·Patrick Anselme
Aug 8, 2007·Progress in Neurobiology·Lisa A BriandMartin Sarter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.