PMID: 11335694May 4, 2001Paper

Cortical activation by tactile and painful stimuli in hemispherectomized patients

Brain : a Journal of Neurology
H OlaussonM C Bushnell

Abstract

Hemispherectomized patients are able to perceive tactile and painful stimuli on their nonparetic as well as paretic body halves. We have used functional MRI to study the cortical mechanisms underlying this preserved somatosensory capacity. Nonpainful brushing and painful heat were applied to the skin of the legs in four hemispherectomized patients and, for comparison, in four normal subjects. Cortical activation was studied with a 1.5 T scanner using a BOLD (blood oxygen level dependent) protocol. All patients rated both the brushing and the heat pain as almost equally intense on each leg and the ratings were similar to those in normals. Brushing on the nonparetic leg activated primary and secondary somatosensory cortices (S1 and S2) in all patients, similar to findings in normals. Brushing on the paretic leg activated S1 in two patients and S2 in one of these patients. Heat pain activated S2, insular cortex and anterior cingulate cortex to a similar degree for both legs, but the activation was weaker in the patients than in the normals. For the individual patient, there was generally no obvious correlation between cortical activation as studied with the BOLD technique and psychophysical performance. The findings from tactile s...Continue Reading

Citations

Jun 25, 2008·Experimental Brain Research·Helena Backlund WaslingHåkan Olausson
Jan 17, 2004·Epilepsy & Behavior : E&B·Guy VingerhoetsAlbert P Aldenkamp
Sep 23, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Massimiliano ValerianiMichele Tinazzi
Apr 15, 2006·Development and Psychopathology·Gary R BrendelDavid A Silbersweig
Nov 18, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L ZhangA Sainsbury
Jul 24, 2001·European Journal of Pain : EJP·H OlaussonM C Bushnell
Sep 10, 2009·Neuroreport·Hiroyuki UmegakiAkihisa Iguchi
Jun 8, 2004·Journal of Biomechanical Engineering·Rafael Davalos, Boris Rubinsky
Jul 14, 2012·Neural Plasticity·Mark W BurkeMaurice Ptito
Jan 24, 2013·Epilepsy Research·Jing ZhangYunlin Li
Dec 6, 2011·Brain & Development·Stella de BodeGary W Mathern
Jul 20, 2002·Brain Research Bulletin·Terence V Sewards, Mark Sewards
Dec 9, 2009·Neuroscience Letters·Mark W BurkeMaurice Ptito
May 6, 2008·The Journal of Pain : Official Journal of the American Pain Society·Heidrun H KrämerChristian Maihöfner
Apr 9, 2008·Neuroscience Letters·Håkan W OlaussonM Catherine Bushnell
Dec 2, 2011·Human Brain Mapping·Emma G Duerden, Marie-Claire Albanese
Feb 15, 2005·Neuropsychologia·H BacklundH Olausson
Jul 30, 2005·Neuroscience Letters·H OlaussonM C Bushnell
Jan 15, 2014·NeuroImage·Stefania FavillaCarlo Adolfo Porro
Jul 12, 2011·Neuroscience Letters·Linda C LundbladHelena Backlund Wasling
Apr 4, 2013·The Journal of Pain : Official Journal of the American Pain Society·Michael E RobinsonDonald D Price
Dec 19, 2009·Neuropsychologia·Julia T ChoiAmy J Bastian
Jan 13, 2004·Pain·Hiroki NakataRyusuke Kakigi
Apr 20, 2005·Pain·Caroline F PukallM Catherine Bushnell
Jan 16, 2016·AJNR. American Journal of Neuroradiology·A MeodedA Poretti
Oct 29, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Carlo A Porro
Jul 30, 2002·Nature Neuroscience·H OlaussonM C Bushnell

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