Cortical activation during cocaine use and extinction in rhesus monkeys.

Psychopharmacology
Leonard L HowellKimberly P Lindsey

Abstract

Acute re-exposure to cocaine or drug cues associated with cocaine use can elicit drug craving and relapse. Neuroimaging studies have begun to define neurobiological substrates underlying the acute effects of cocaine or cocaine cues in cocaine-dependent subjects. The present study was the first to use functional brain imaging to document acute cocaine-induced changes in brain activity during active drug use in nonhuman primates. Positron emission tomography imaging with O15-labeled water was used to measure drug-induced changes in cerebral blood flow. The acute effects of cocaine administered noncontingently were characterized in four drug-naïve rhesus monkeys. The same subjects were trained to self-administer cocaine under a fixed ratio schedule during image acquisition. Subsequently, three subjects with an extensive history of cocaine use were trained to self-administer cocaine under a second-order schedule. The same subjects also underwent extinction sessions during which saline was substituted for cocaine under the second-order schedule. Noncontingent administration of cocaine in drug-naïve subjects induced robust activation of prefrontal cortex localized primarily to the dorsolateral regions. In contrast, the pattern of bra...Continue Reading

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Citations

Mar 2, 2011·Psychopharmacology·Kevin S Murnane, Leonard L Howell
Aug 17, 2012·Psychopharmacology·Michael A NaderDrake Morgan
Aug 4, 2010·Brain Imaging and Behavior·Porche' Kirkland HenryLeonard L Howell
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Oct 21, 2011·Nature Reviews. Neuroscience·Rita Z Goldstein, Nora D Volkow
Feb 15, 2011·The Journal of Pharmacology and Experimental Therapeutics·Leonard Lee Howell, Kevin Sean Murnane
Aug 16, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin S MurnaneLeonard L Howell
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Jan 16, 2016·Journal of Cardiovascular Pharmacology·Robert M RapoportMario Zuccarello
May 23, 2017·ILAR Journal·Matthew L BanksSidney S Negus

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