Cortical and hippocampal volume deficits in temporal lobe epilepsy

Epilepsia
L MarshA Pfefferbaum

Abstract

To use quantitative magnetic resonance imaging (MRI) methods to examine the extent of volume abnormalities in the hippocampus and in extrahippocampal brain regions in localization-related epilepsy of temporal lobe origin (TLE). Hippocampal, temporal lobe, and extratemporal lobe volumes were examined with 3-mm spin-echo coronal MRI scans in patients with unilateral TLE who were candidates for temporal lobe resection. Measures were adjusted for normal variation due to intracranial volume and age based on 72 healthy male controls. Group differences between 14 male TLE [7 left TLE (LTLE), 7 right TLE (RTLE)] patients and a subset of 49 age range-matched controls were examined with analysis of variance (ANOVA). As compared with controls, patients with TLE had smaller temporal lobe and frontoparietal region gray matter volumes, bilaterally, smaller temporal lobe white matter volumes bilaterally, and larger ventricular volumes. In contrast to these bilateral tissue volume deficits, hippocampal volume deficits in TLE were ipsilateral to the epileptogenic temporal lobe. Extrahippocampal volume abnormalities were bilateral and occurred in both temporal and extra-temporal cortical regions in TLE, whereas hippocampal deficits were related ...Continue Reading

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Citations

Oct 29, 2002·Annals of Neurology·Rebecca S N LiuJohn S Duncan
May 10, 2001·Hippocampus·J Ferbinteanu, R J McDonald
Sep 5, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Giampiero GiovacchiniWilliam H Theodore
Nov 9, 2007·Neuropsychology Review·Michael SeidenbergBruce Hermann
May 18, 2004·Epilepsy & Behavior : E&B·Lisa BarthaThomas Benke
Jul 25, 2003·Magnetic Resonance Imaging·Colin P DohertyHugh Staunton
Nov 1, 2003·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·E M Zipf-WilliamsM J Morrell
Mar 1, 2003·Epilepsy & Behavior : E&B·Daniel L. Drane, Kimford J. Meador
Apr 19, 2008·Journal of the International Neuropsychological Society : JINS·Michael SeidenbergLeslie Guidotti
Oct 9, 2002·Epilepsia·Susanne G MuellerMichael W Weiner
Jan 3, 2001·Brain : a Journal of Neurology·N F MoranS D Shorvon
Jan 19, 2006·Epilepsia·Tayo O OyegbileBruce P Hermann
Feb 14, 2007·Epilepsia·Regula S BriellmannGraeme D Jackson
May 19, 2007·Epilepsia·Luis ConchaDonald W Gross
Jan 30, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Regula S BriellmannGraeme D Jackson
Jun 17, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·H Jokeit, A Ebner
Jun 11, 2009·AJNR. American Journal of Neuroradiology·M E AhmadiE Halgren
Jan 28, 2012·AJNR. American Journal of Neuroradiology·E WidjajaM L Smith
May 24, 2012·Neuroscience and Biobehavioral Reviews·Radwa A B BadawyAnthony S Harvey
Jul 29, 2011·Epilepsy & Behavior : E&B·Carrie R McDonaldBruce Schefft
Jul 23, 2011·Neurobiology of Disease·Masataka NishimuraJohn W Swann
Oct 6, 2010·Epilepsy & Behavior : E&B·Ivaldo SilvaDébora Amado
Apr 20, 2010·Pediatric Neurology·Elysa WidjajaMary Lou Smith
Mar 13, 2010·Epilepsy Research·Maria Teresa Castilho Garcia SantanaElza Márcia Targas Yacubian
Oct 27, 2009·Neurologic Clinics·Bruce P HermannMichael Seidenberg

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