PMID: 6538142Mar 1, 1984Paper

Cortical and subcortical EEG patterns during moderate-intensity barbiturate withdrawal

Experimental Neurology
D J Hinman, M Okamoto

Abstract

Electroencephalograms were recorded from cortical and subcortical brain regions during moderate-intensity barbiturate withdrawal in the cat. Physical dependence was produced by administration of Na-barbital by the "low dose barbiturate" treatment schedule. During moderate-intensity withdrawal, the EEG pattern showed 4- to 6-Hz rhythmic bursts in the hippocampus, visual cortex, auditory cortex, motor cortex, nucleus centralis centralis of the thalamus, caudate nucleus, and lateral geniculate body. The bursts in the hippocampus were spike-and-wave type. In animals which had spontaneous seizures, 4- to 6-Hz bursts occurred in the motor cortex, whereas this abnormality did not occur in the motor cortex in animals which did not have spontaneous generalized seizures. In addition, prolonged high-frequency, high-voltage discharges and spikes were recorded from the amygdala during withdrawal. Spontaneous generalized or partial seizures occurred during withdrawal; the abnormal EEG patterns associated with seizures appeared to originate in various subcortical sites. Perhaps the most important result was the finding that no one brain region or set of brain regions seemed to be specifically involved in barbiturate withdrawal.

Citations

Jan 1, 1994·British Journal of Pharmacology·M RabbaniH J Little

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.