Cortical and subcortical white matter damage without Wernicke's encephalopathy after recovery from thiamine deficiency in the rat

Alcoholism, Clinical and Experimental Research
P J Langlais, S X Zhang

Abstract

The relative etiologic roles of ethanol and thiamine deficiency in the cortical atrophy and loss of cerebral white matter in chronic alcoholics are uncertain. The present study examined the distribution of degenerating axons within cortical and subcortical tracts 1 week after recovery from early to late symptomatic stages of thiamine deficiency in the absence of ethanol in Sprague-Dawley rats. The brains of rats exposed to an early symptomatic stage of pyrithiamine-induced thiamine deficiency, 12-13 days of treatment, contained degenerating axons in corpus callosum, anterior commissure, external and internal capsules, optic and olfactory tracts, and fornix and mammillothalamic tracts. A dense pattern of degenerating axons was evident in layers III-IV of frontal and parietal cortex. Less intense and more evenly distributed degenerating axons were present in layers IV-VI of frontal, parietal, cingulate, temporal, retrosplenial, occipital, and granular insular cortex. Neuronal counts in mammillary body nuclei and areal measurements of the mammillary body were unchanged from controls and the thalamus was relatively undamaged. In animals reversed at later and more advanced symptomatic stages of thiamine deficiency, 14-15 days of tre...Continue Reading

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Citations

Jun 1, 1997·Metabolic Brain Disease·P J LanglaisS C Bondy
Dec 3, 2011·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Laurie M McCormickSergio Paradiso
Sep 14, 2013·Psychopharmacology·Natalie M ZahrAdolf Pfefferbaum
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May 12, 2009·Neurochemistry International·Alan S Hazell
May 14, 2008·The International Journal of Eating Disorders·Laurie M McCormickNancy Andreasen
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Sep 19, 2006·Neurobiology of Learning and Memory·Jessica J Roland, Lisa M Savage
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Jun 24, 2006·Alcoholism, Clinical and Experimental Research·Adolf PfefferbaumEdith V Sullivan
Oct 18, 2020·Alcoholism, Clinical and Experimental Research·Bradley J ChattertonLisa M Savage

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