Cortical and trabecular bone distribution in the femoral neck in osteoporosis and osteoarthritis

Bone
Hubert BlainPierre D Delmas

Abstract

The increased hip fragility in osteoporosis has been attributed mainly to a thinning of the cortex. In contrast, hip arthritis (OA) is not associated with increased risk of hip fracture. The purpose of this study was to assess cortical and trabecular bone structures and their possible regional variability in the femoral neck taken from patients who sustained an osteoporotic hip fracture (OP) compared with patients with OA. We compared the distribution of bone in the ultradistal femoral neck in 21 postmenopausal women with OA (mean age: 66+/-7.8 years) and 20 postmenopausal women with an osteoporotic hip fracture (OP) (mean age: 79.5+/-1.9 years). Controlateral hip osteoporosis or osteopenia was confirmed in OP by DEXA (T-score: -2.5+/-0.8 in OP; -0.9+/-1.3 in OA). Histomorphometric parameters of bone structure, architecture and connectivity were measured on sections from the ultradistal part of the femoral neck, divided in 4 quadrants. When compared to OA, cortical thickness was significantly decreased in OP (p<0.0005) but was the highest in the inferior part in both groups. Cortical porosity was higher in OA (13.48+/-1.02 and 8.4+/-1.07% in OA and OP respectively). Compared to OA, the trabecular bone volume was decreased by 50...Continue Reading

References

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Citations

Sep 29, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A RubinacciG Rizzo
Sep 9, 2010·Annals of Biomedical Engineering·G RizzoA Rubinacci
Jul 26, 2011·Annals of Biomedical Engineering·F S GayzikJ D Stitzel
Sep 6, 2012·Medical & Biological Engineering & Computing·Khairul Salleh BasaruddinTakayoshi Nakano
Jun 7, 2013·EJNMMI Research·Michal CachovanTorsten Kuwert
Sep 23, 2014·The Journal of the Acoustical Society of America·Pierre NauleauClaire Prada
Apr 17, 2012·The Journal of the Acoustical Society of America·Pierre NauleauClaire Prada
Dec 30, 2015·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Louise V CouttsUNKNOWN OStEO Study Team
Jan 24, 2009·Bone·E TanckB Van Rietbergen
May 16, 2012·Clinical Biomechanics·A AndreykivE R Valstar
Jul 22, 2014·Osteoarthritis and Cartilage·M Y ChanT V Nguyen
Apr 14, 2016·Acta ortopedica brasileira·Caio Gonçalves de SouzaLuciene Machado Dos Reis
Jul 31, 2013·Clinical Orthopaedics and Related Research·Matthias KrauseFlorian Barvencik
Jun 10, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Tommaso MalutaBruno Magnan
Dec 20, 2019·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Richard P BakerGordon C Bannister
May 5, 2020·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Shengnan LiuShaoting Liu
Jun 7, 2017·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Baolin LiJianfeng Fei
Jul 20, 2018·Calcified Tissue International·Gustavo D RabeloPascale Chavassieux

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