Cortical and trabecular bone mineral content in women with endometriosis: effect of gonadotropin-releasing hormone agonist and danazol

Fertility and Sterility
M Y DawoodJ Ramos

Abstract

Cortical bone (distal radius and ulna) and trabecular bone mineral content of the thoracolumbar vertebrae (T-12 to L-4) were measured with single-photon absorptiometry and quantitative computed tomography, respectively, in 55 women with laparoscopically staged endometriosis before, during, and after treatment with a gonadotropin-releasing hormone agonist (GnRH-a) or danazol. Mean pretreatment potassium phosphate mineral contents of T-12 to L-4 were 174 to 201 mg/ml in stage I to IV endometriosis and were within the 100 to 115th percentile of normal women. Similarly, cortical bone mineral contents were normal and were not significantly affected by either medication. Trabecular bone decreased significantly to 92.6 +/- 1.7% (n = 11, P less than 0.001) and 92.3 +/- 2.5% (n = 7, P less than 0.01) of baseline year after 6 months and 9 months of GnRH-a treatment and remained significantly depressed at 95.8 +/- 1.9% (P less than 0.0025) and 94.8 +/- 2.5% (P less than 0.005) 6 months after stopping treatment. Thus, cortical and trabecular bone mineral contents of women with endometriosis are normal, but treatment with GnRH-a induced significant loss of trabecular bone.

Citations

Nov 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Goulding, L Fisher
Dec 1, 1990·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·O YlikorkalaL Viinikka
Sep 1, 1993·Asia-Oceania Journal of Obstetrics and Gynaecology·M FukushimaK Sato
Jul 20, 2007·The Cochrane Database of Systematic Reviews·A PrenticeS K Smith
May 24, 2008·Reproductive Sciences·Sang-Hoon KwonChi-Heum Cho
Oct 2, 2013·Journal of Obstetrics and Gynaecology of India·Vikram Sinai TalaulikarIsaac Manyonda
Jan 1, 1997·Calcified Tissue International·M GambaccianiA R Genazzani
Sep 1, 1997·The Journal of Clinical Endocrinology and Metabolism·A TomkinsonB S Noble
May 1, 1995·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C RouxB Amor
Mar 26, 2005·Human Reproduction Update·J Vrbíková, D Cibula
Sep 16, 2005·Plastic and Reconstructive Surgery·Christopher J SalgadoHung-Chi Chen
Jan 13, 2016·Clinical Obstetrics and Gynecology·Chantal B BartelsJames H Segars
Sep 1, 1995·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M Fukushima
Oct 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Stefano PalombaFulvio Zullo
Oct 30, 2003·The Cochrane Database of Systematic Reviews·M SagsveenA Breeze
May 1, 1994·British Journal of Obstetrics and Gynaecology·I FogelmanA T Leather
Jun 24, 1998·British Journal of Obstetrics and Gynaecology·A Pickersgill
Jun 16, 1999·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A T LeatherE F Holland
Nov 26, 1999·Current Problems in Diagnostic Radiology·S JaovisidhaD J Sartoris
Dec 10, 2019·Journal of Pediatric and Adolescent Gynecology·Jessica Y Shim, Marc R Laufer

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