Cortical and trabecular deterioration in mouse models of Roux-en-Y gastric bypass

Bone
Elaine W YuMary L Bouxsein

Abstract

Roux-en-Y gastric bypass (RYGB) is a profoundly effective treatment for severe obesity, but results in significant bone loss in patients. Developing a murine model that recapitulates this skeletal phenotype will provide a robust tool with which to study the physiologic mechanisms of this bone loss. We studied adult male C57BL/6J mice who underwent either RYGB or sham operation. Twelve weeks after surgery, we characterized biochemical bone markers (parathyroid hormone, PTH; C-telopeptide, CTX; and type 1 procollagen, P1NP) and bone microarchitectural parameters as measured by microcomputed tomography. RYGB-treated mice had significant trabecular and cortical bone deficits compared with sham-operated controls. Although adjustment for final body weight eliminated observed cortical differences, the trabecular bone volume fraction remained significantly lower in RYGB mice even after weight adjustment. PTH levels were similar between groups, but RYGB mice had significantly higher indices of bone turnover than sham controls. These data demonstrate that murine models of RYGB recapitulate patterns of bone loss and turnover that have been observed in human clinical studies. Future studies that exploit this murine model will help delineat...Continue Reading

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Citations

Mar 3, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elaine W YuSeoyoung C Kim
May 28, 2019·Scientific Reports·Michael B MumphreyHans-Rudolf Berthoud
Oct 21, 2019·Obesity Surgery·Matthew StevensonLouis Ragolia
May 8, 2019·The Journal of Clinical Investigation·Ziru LiOrmond A MacDougald
Dec 28, 2019·The Journal of Steroid Biochemistry and Molecular Biology·H JiangJ C Fleet
Aug 21, 2021·Bone·Florêncio Diniz-SousaHélder Fonseca

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