PMID: 7541447Jul 1, 1995Paper

Cortical architectural abnormalities and MIB1 immunoreactivity in gangliogliomas: a study of 60 patients with intracranial tumors

Journal of Neuropathology and Experimental Neurology
Richard A PraysonY G Comair

Abstract

Gangliogliomas are generally low grade neoplasms composed of mixtures of neoplastic glial and neuronal elements whose origin and exact nature are still controversial. We studied a series of 60 intracranial gangliogliomas looking for coexistent cortical architectural abnormalities (cortical dysplasia, microdysgenesis) and to determine if tumor behavior correlates with MIB1 (marker of cellular proliferation) labeling. The patients included 34 males and 26 females who ranged in age from 6 months to 55 years (mean 20 years). Thirty-eight tumors (63%) were located in the temporal lobe and 6 (10%) in the frontal lobe. Fifty-four patients (90%) presented with seizures (most with intractable epilepsy) and the duration of seizures ranged from 1 to 38 years (mean 14 years). In all cases, the predominant glioma component resembled a low grade fibrillary astrocytoma. In 14 tumors (23%), an oligodendroglial component was present. In one case, the glial component resembled an anaplastic astrocytoma. The tumors were characterized variously by perivascular chronic inflammation (N = 45, 75%), vascular proliferation (N = 36, 60%), granular bodies (N = 54, 90%), binucleated neurons (N = 36, 60%), calcification (N = 28, 47%), and cystic degenerati...Continue Reading

Citations

Apr 29, 1998·Current Opinion in Neurology·W Boling, A Olivier
Sep 22, 2001·Journal of Neurosurgery·N DuggalR R Hammond
Mar 27, 2010·Neurologia Medico-chirurgica·Tomoyuki KawatakiHiroyuki Kinouchi
Mar 18, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Thotadamane Nagaraja ChandrashekharSusarla Krishna Shankar
Oct 4, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Gianluca MarucciMarco Giulioni
Sep 13, 2019·Neurology India·Vivek TandonManjari Tripathi
May 30, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P E McKeever
Apr 29, 1998·Cancer·J Blatt, R L Hamilton
Nov 1, 1996·Pathology International·R A Prayson, M L Estes
May 20, 1998·The American Journal of Surgical Pathology·B Quinn
Nov 18, 2005·Journal of Neuro-oncology·Audrey RousseauJean-Jacques Hauw
Jun 5, 2010·Journal of Neuro-oncology·Ryan DeMarchiR Loch Macdonald
Aug 4, 2011·Archives of Pathology & Laboratory Medicine·Trent Marburger, Richard Prayson
Jul 5, 2011·Brain Tumor Pathology·Shinji YamashitaHideo Takeshima
Dec 1, 2007·Expert Opinion on Medical Diagnostics·Fatima W Khwaja
Jul 16, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Murat Şakir EkşiTürker Kılıç
May 28, 2002·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hiroyoshi SuzukiHidehiro Takei
Aug 17, 2006·Brain Pathology·Jorge E DottoSergei I Bannykh
Dec 8, 2006·Journal of Neuro-oncology·Amin AminiMeic H Schmidt
Jul 20, 2002·Journal of Neuropathology and Experimental Neurology·Ingmar Blümcke, Otmar D Wiestler
Apr 24, 2010·The American Journal of Surgical Pathology·Richard A Prayson
Dec 23, 2008·Advances in Anatomic Pathology·Daniela S Allende, Richard A Prayson
May 25, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Richard A PraysonImad Najm
Apr 14, 2012·Brain Pathology·Maria ThomEleonora Aronica
Feb 2, 2017·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Seiji YamadaHideaki Yokoo
Jul 1, 1997·The American Journal of Surgical Pathology·A PerryS Shapiro
Jun 1, 2005·Journal of Neuro-oncology·Takao FukushimaTakakazu Yokoyama
Aug 17, 2005·American Journal of Clinical Pathology·Kymberly A Gyure
Dec 2, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Kenta MasuiToru Iwaki
Mar 20, 2012·Brain : a Journal of Neurology·A James BarkovichWilliam B Dobyns
Feb 17, 2010·Neuro-oncology·Margaret J DoughertyJaclyn A Biegel
Oct 31, 2014·Annals of Clinical and Translational Neurology·Gianluca MarucciGiovanni Tallini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.