Cortical bone development in black and white South African children: iliac crest histomorphometry

Bone
C M SchnitzlerJ M Pettifor

Abstract

Fragility fracture rates in South Africa are lower in blacks (B) than in whites (W) both in adults and in children. In adults this difference may in part be explained by histomorphometric findings in iliac crest cortical bone of B of thicker, less porous cortices, greater endocortical (Ec) wall thickness, fewer canals and greater osteoid thickness accompanied by greater mineral apposition rate and bone formation rate compared to W. Since no comparative data for B and W children are available we examined iliac crest cortical bone of 57 B and 56 W aged 0-23 yrs by routine histomorphometry. The effects of growth as expressed in differences between external and internal cortex were similar in B and W children. Cortical thickness increased with age similarly in B and W until about age 15 whereafter it continued to increase only in B. Ec wall thickness rose with age in B but did not change in W. After age 11 canal number was lower in B. Cortical porosity was highest between ages 6 and 15 with a tendency to lower values in the external cortex in B. Thus structural differences reported in adults were evident in children. Bone turnover as reflected in osteoid surface and eroded surface declined with age similarly in B and W but osteoid ...Continue Reading

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Citations

Sep 18, 2010·Calcified Tissue International·Takeshi MatsumotoKentaro Uesugi
Apr 26, 2011·Journal of Bone and Mineral Metabolism·Lisa K MicklesfieldJohn M Pettifor
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May 1, 2021·International Journal of Molecular Sciences·Matthias MährNadja Fratzl-Zelman

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