Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis

Arthritis Research & Therapy
Anna NeumannGeorg Schett

Abstract

In the present study, we investigated bone geometry, microstructure, and volumetric bone mineral density (vBMD) in a cohort of patients with nonradiographic axial spondyloarthritis (nr-axSpA) in order to define the early bone changes occurring in axial spondyloarthritis (axSpA) and to define potential factors for deterioration of bone microstructure. Patients with axSpA (n = 107) and healthy control subjects (n = 50) of similar age and sex were assessed for geometric, volumetric, and microstructural parameters of bone using high-resolution peripheral quantitative computed tomography (HR-pQCT) at the radius. Additionally, demographic and disease-specific characteristics of patients with axSpA were recorded. Patients with nr-axSpA and control subjects were comparable in age, sex, and body mass index. Geometric and microstructural analysis by HR-pQCT revealed a significantly reduced cortical area (p = 0.022) and cortical thickness (p = 0.006) in patients with nr-axSpA compared with control subjects. Total and cortical vBMD were significantly reduced in patients with nr-axSpA (p = 0.042 and p = 0.007, respectively), whereas there was no difference in trabecular vBMD. Patients with a short disease duration (< 2 years; n = 46) also s...Continue Reading

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Citations

Nov 27, 2019·International Journal of Molecular Sciences·Giovanni AdamiDavide Gatti
Mar 12, 2020·Rheumatology·Elizabeth G Araujo, Georg Schett
Sep 30, 2020·Seminars in Musculoskeletal Radiology·Chiara GiraudoSiegfried Trattnig
Dec 11, 2020·Bone·Johannes GrillariMatthias Hackl
Jan 2, 2021·International Journal of Molecular Sciences·Constanze S SchwarzIl-Kang Na
Dec 29, 2020·Frontiers in Medicine·Mie Jin Lim, Kwi Young Kang
Jul 16, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A DemingerH Forsblad-d'Elia

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Methods Mentioned

BETA
X-ray
biopsy
ESR

Software Mentioned

Xtreme
SPSS

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