Cortical Bone Mapping: Measurement and Statistical Analysis of Localised Skeletal Changes

Current Osteoporosis Reports
Graham M Treece, Andrew H Gee

Abstract

Cortical bone mapping (CBM) is a technique for measuring localised skeletal changes from computed tomography (CT) images. It can provide measurements with accuracy surpassing the underlying imaging resolution. CBM can detect changes in several properties of the cortex, with no prior assumptions about the likely location of said changes. This paper summarises the theory behind CBM, discusses its strengths and limitations, and reviews some studies in which it has been applied. CBM has revealed associations between fracture risk and cortical properties in specific regions of the proximal femur which present feasible therapeutic targets. Analyses of several pharmaceutical and exercise interventions quantify effects that are distinct both in location and in the nature of the micro-architectural changes. CBM has illuminated age-related changes in the proximal femur and has recently been applied to other bones, as well as to the assessment of cartilage. The CBM processing pipeline is designed primarily for large cohort studies. Its main impact thus far has not been in the realm of clinical practice, but rather to improve our fundamental understanding of localised bone structure and changes.

References

Oct 12, 2007·Medical Physics·G J StreekstraH W Venema
Feb 19, 2010·Medical Image Analysis·G M TreeceK E S Poole
Jan 26, 2011·PloS One·Kenneth E S PooleAndrew H Gee
Apr 3, 2012·Medical Image Analysis·G M TreeceA H Gee
Jun 1, 2013·Current Osteoporosis Reports·Julio Carballido-Gamio, Daniel P Nicolella
Aug 21, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K K NishiyamaS K Boyd
Jan 21, 2014·Medical Image Analysis·Andrew H Gee, Graham M Treece
Aug 5, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kenneth E S PooleCesar Libanati
Nov 29, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roger Zebaze, Ego Seeman
Dec 3, 2014·Journal of Anatomy·Elizabeth M LillieJoel D Stitzel
Feb 3, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tristan WhitmarshKenneth E S Poole
Mar 11, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sarah J AllisonKatherine Brooke-Wavell
May 20, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Graham M TreeceUNKNOWN Osteoporotic Fractures in Men (MrOS) Study
Aug 11, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elizabeth M LillieJoel D Stitzel
Aug 19, 2015·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Klaus EngelkeJohn T Shousboe
Oct 8, 2015·European Radiology·Tom D TurmezeiKenneth E S Poole
Mar 15, 2016·Medical Engineering & Physics·Ju ZhangThor F Besier
Apr 14, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Catherine OkoukoniJeffrey S Willey
Nov 4, 2016·Annals of Biomedical Engineering·Amirreza PakdelCari Whyne
Oct 26, 2016·Bone·Kenneth E S PooleGraham M Treece
Oct 28, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Penny R AtkinsAndrew E Anderson
Nov 11, 2016·Annals of Biomedical Engineering·Julio Carballido-GamioAndrew J Burghardt
Jan 31, 2017·Current Osteoporosis Reports·Robyn K FuchsStuart J Warden
Apr 14, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Aihong YuXiaoguang Cheng
Nov 28, 2017·Medical Image Analysis·R A Pearson, G M Treece

❮ Previous
Next ❯

Citations

Oct 8, 2019·The Journal of Clinical Endocrinology and Metabolism·Luis Gracia-MarcoManuel Muñoz-Torres
Nov 16, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M T LöfflerT Baum
May 25, 2020·Journal of Magnetic Resonance Imaging : JMRI·James W MacKayFiona J Gilbert
Feb 13, 2021·Journal of Clinical Medicine·Luis Gracia-MarcoManuel Muñoz-Torres
Nov 7, 2021·Current Osteoporosis Reports·Valentina PedoiaSharmila Majumdar
Nov 6, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kenneth Es PooleTristan Whitmarsh

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

SPM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved