Cortical bone vessel identification and quantification on contrast-enhanced MR images

Quantitative Imaging in Medicine and Surgery
Po-Hung WuGalateia J Kazakia

Abstract

Cortical bone porosity is a major determinant of bone strength. Despite the biomechanical importance of cortical bone porosity, the biological drivers of cortical porosity are unknown. The content of cortical pore space can indicate pore expansion mechanisms; both of the primary components of pore space, vessels and adipocytes, have been implicated in pore expansion. Dynamic contrast-enhanced MRI (DCE-MRI) is widely used in vessel detection in cardiovascular studies, but has not been applied to visualize vessels within cortical bone. In this study, we have developed a multimodal DCE-MRI and high resolution peripheral QCT (HR-pQCT) acquisition and image processing pipeline to detect vessel-filled cortical bone pores. For this in vivo human study, 19 volunteers (10 males and 9 females; mean age =63±5) were recruited. Both distal and ultra-distal regions of the non-dominant tibia were imaged by HR-pQCT (82 µm nominal resolution) for bone structure segmentation and by 3T DCE-MRI (Gadavist; 9 min scan time; temporal resolution =30 sec; voxel size 230×230×500 µm3) for vessel visualization. The DCE-MRI was registered to the HR-pQCT volume and the voxels within the MRI cortical bone region were extracted. Features of the DCE data were ...Continue Reading

Citations

Jan 23, 2021·Anatomical Science International·Tahlia J StewartJustyna J Miszkiewicz
Oct 10, 2021·Acta Biomaterialia·Benjamin DalissonJake Barralet
Nov 7, 2021·Current Osteoporosis Reports·Valentina PedoiaSharmila Majumdar

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