Cortical consequences of HIV-1 Tat exposure in rats are enhanced by chronic cocaine

Current HIV Research
Wesley N WaymanT Celeste Napier

Abstract

The life span of individuals that are sero-positive for human immunodeficiency virus (HIV) has greatly improved; however, complications involving the central nervous system (CNS) remain a concern. While HIV does not directly infect neurons, the proteins produced by the virus, including HIV transactivator of transcription (Tat), are released from infected glia; these proteins can be neurotoxic. This neurotoxicity is thought to mediate the pathology underlying HIVassociated neurological impairments. Cocaine abuse is common among HIV infected individuals, and this abuse augments HIV-associated neurological deficits. The brain regions and pathophysiological mechanisms that are dysregulated by both chronic cocaine and Tat are the focus of the current review.

Citations

Mar 6, 2016·Journal of Neuroimmunology·William C ReidDima A Hammoud
Dec 19, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wesley N WaymanT C Napier
Apr 2, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Francesca Isabella De SimoneKamel Khalili
Sep 18, 2015·Journal of Neuroinflammation·Dianne E LeeDima A Hammoud
Dec 6, 2017·Journal of Cellular Physiology·Taha Mohseni AhooyiJennifer Gordon
May 22, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Leah H RubinJeffrey R Bishop
Dec 3, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·T Celeste Napier

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